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t-Butylhydroquinone (CAS 1948-33-0)

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Synonym:TBHQ; 2-tert-butylbenzene-1,4-diol
Application:An inhibitor of the endoplasmic reticulum Ca2+-ATPase and activator of ERK2
CAS Number:1948-33-0
Molecular Weight:166.22
Molecular Formula:C10H14O2
Refer to Certificate of Analysis for lot specific data (including water content).
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t-Butylhydroquinone sc-202825 10 g $31
t-Butylhydroquinone is a phenolic antioxidant functioning as an inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase). In addition, t-Butylhydroquinone activates ERK2 (extracellular signal-regulated protein kinase 2) which was late and prolonged compared to butylated hydroxyanisole (sc-252527), a similar phenolic antioxidant. Moreover, studies suggest that t-Butylhydroquinone requires the help of an upstream signaling kinase MAPK/ERK kinase (MEK) in order to activate ERK2. It has been reported that t-Butylhydroquinone reduces the intracellular concentration of H2O2 which are byproducts generated during the MAPK pathway. Alternate studies indicate that t-Butylhydroquinone can increase cytosolic and mitochondrial thioredoxin reductase activity in cortical astrocytes.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO, methanol, water (10 g/l) at 20° C, acetone, ethanol, ethyl acetate, and propylene glycol (30 %) at 25° C. Solubility in fats and food-grade solvents is good. Insoluble in benzene.
Storage:Store at room temperature
Melting Point:127-129° C (lit.)
Boiling Point:295° C at 760 mmHg
Density:1.05 g/cm3 at 20° C
Refractive Index:n20D 1.55 (Predicted)
pK Values:pKa: 10.80
Safety and Reference Information
WGK Germany:3
PubChem CID:16043
MDL Number:MFCD00002344
EC Number:217-752-2
Beilstein Registry:637923
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1. Yu, R., et al. 1997. J. Biol. Chem. 272: 28962-28970. PMID: 9360968
2. Eftekharpour, E., et al. 2000. Glia. 31: 241-248. PMID: 10941150
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