Molecular structure of SIRT2 Inhibitor, AGK2, CAS Number: 304896-28-4
SIRT2 Inhibitor, AGK2 (CAS 304896-28-4)
See product citations (5)
Alternate Names:
2-cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-5-quinolinylacrylamide
Application:
SIRT2 Inhibitor, AGK2 is a reversible inhibitor of SIRT2 activity
CAS Number:
304896-28-4
Purity:
≥95%
Molecular Weight:
434.27
Molecular Formula:
C23H13Cl2N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SIRT2 Inhibitor, AGK2 is a reversible inhibitor of sirtuin 2 (SIRT2), a histone deacetylase enzyme. Inhibition of SIRT2 has been correlated to protection against dopaminergic cell death in Parkinson′s disease models, and is also shown to rescue cells from toxicity conferred by alpha-synuclein expression. SIRT2 Inhibitor, AGK2 has little activity against SIRT1 and SIRT3 (IC50 >50 muM).
SIRT2 Inhibitor, AGK2 (CAS 304896-28-4) References
- Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. | Auluck, PK., et al. 2002. Science. 295: 865-8. PMID: 11823645
- Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. | Outeiro, TF., et al. 2007. Science. 317: 516-9. PMID: 17588900
- Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells. | Li, Y., et al. 2013. Neurosci Lett. 544: 36-40. PMID: 23570735
- Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer. | Ma, W., et al. 2018. Cancer Biol Ther. 19: 835-846. PMID: 30067423
- AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo. | Yu, HB., et al. 2018. Int J Med Sci. 15: 1356-1364. PMID: 30275764
- AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1. | Jiao, F., et al. 2020. J Neuroimmune Pharmacol. 15: 196-208. PMID: 31786712
- AGK2 ameliorates mast cell-mediated allergic airway inflammation and fibrosis by inhibiting FcεRI/TGF-β signaling pathway. | Kim, YY., et al. 2020. Pharmacol Res. 159: 105027. PMID: 32565308
- SIRT2 ablation inhibits glucose-stimulated insulin secretion through decreasing glycolytic flux. | Zhou, F., et al. 2021. Theranostics. 11: 4825-4838. PMID: 33754030
- NAD+-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin. | Li, DJ., et al. 2021. Theranostics. 11: 4381-4402. PMID: 33754067
- SIRT1 and SIRT2 modulators reduce LPS-induced inflammation in HAPI microglial cells and protect SH-SY5Y neuronal cells in vitro. | Zhang, Y., et al. 2021. J Neural Transm (Vienna). 128: 631-644. PMID: 33821324
- MYO1F regulates antifungal immunity by regulating acetylation of microtubules. | Sun, W., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34301894
- Inhibition of Sirt2 Alleviates Fibroblasts Activation and Pulmonary Fibrosis via Smad2/3 Pathway. | Gong, H., et al. 2021. Front Pharmacol. 12: 756131. PMID: 34925016
- Assessment of Pharmacological Interactions between SIRT2 Inhibitor AGK2 and Paclitaxel in Different Molecular Subtypes of Breast Cancer Cells. | Wawruszak, A., et al. 2022. Cells. 11: PMID: 35406775
Inhibitor of:
Ataxin-7, NAIP5, NAIP6, SG2NA, Sir2, Sir3, SIRT1, SIRT2, SIRT4, SIRT5, SIRT6, Stat1, and SUT-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SIRT2 Inhibitor, AGK2, 1 mg | sc-202813A | 1 mg | $45.00 | |||
SIRT2 Inhibitor, AGK2, 5 mg | sc-202813 | 5 mg | $145.00 | |||
SIRT2 Inhibitor, AGK2, 10 mg | sc-202813B | 10 mg | $310.00 | |||
SIRT2 Inhibitor, AGK2, 25 mg | sc-202813C | 25 mg | $480.00 |