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Scoparone (CAS 120-08-1)

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Synonym:6,7-Dimethylesculetin, 6,7-Dimethoxycoumarin
Application:An agent that can up-regulate the expression and activate CAR
CAS Number:120-08-1
Purity:≥98%
Molecular Weight:206.20
Molecular Formula:C11H10O4
Refer to Certificate of Analysis for lot specific data (including water content).
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Scoparone sc-202806 25 mg $105
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Description
Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin (sc-202499) by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII© in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (15 mg/ml), and water (partly miscible).
Storage:Store at 4° C
Melting Point:143-145 °C (lit.)
Boiling Point:327.2-411.2 °C at 760 mmHg (Predicted)
Density:1.2 g/cm3 (Predicted)
Refractive Index:n20D 1.56 (Predicted)
IC50:fMLP/cytochalasin B-induced superoxide radical anion generation : IC50 = 41.4 µM (human neutrophils )
Safety and Reference Information
Transport:UN 2811, Class 6.1, Packing group III
WGK Germany:3
RTECS:GN6550000
PubChem CID:8417
Merck Index:14: 8404
MDL Number:MFCD00006871
EC Number:204-369-0
SMILES:COC1=C(C=C2C(=C1)C=CC(=O)O2)OC
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Baader, M., et al. 2002. J. Biol. Chem. 277: 15647-15653. PMID: 11867618
2. Lee, Y.M., et al. 2003. J. Biomed. Sci. 10: 518-525. PMID: 12928592
3. Huang, W., et al. 2004. J. Clin. Invest. 113: 137-143. PMID: 14702117
4. Lazar, M.A., et al. 2004. J. Clin. Invest. 113: 23-25. PMID: 14702104
5. Yang, Y.J., et al. 2008. Neurosci. Lett. 440: 14-18. PMID: 18547723
6. Yang, Y.J., et al. 2009. J. Neurosci. Res. 87: 1929-1937. PMID: 19185027
7. Yang, Y.J., et al. 2010. Fitoterapia. 81: 497-502. PMID: 20080157
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