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PPADS tetrasodium salt, anhydrous (CAS 192575-19-2)

Synonym:Pyridoxalphosphate-6-azophenyl-2',4'- disulfonic acid tetrasodium salt
Application:A selective P2 purinergic antagonist that acts both pre and post junctional
CAS Number:192575-19-2
Molecular Weight:599.30
Molecular Formula:C14H10N3O12PS2•Na4
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
PPADS tetrasodium salt, anhydrous sc-202770 10 mg $75
PPADS tetrasodium salt, anhydrous sc-202770A 50 mg $289
PPADS tetrasodium salt is a non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5 (IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4 (IC50 ~ 15 mM) receptors.
Technical Information
Physical State:Solid
Solubility:Soluble in water (100 mM).
Storage:Store at -20° C
Refractive Index:n20D 1.73 (Predicted)
IC50:P2X purinoceptor 1: IC50 = 99 nM (rat); P2X purinoceptor 3: IC50 = 240 nM (rat); P2X purinoceptor 2: IC50 = 1.6 µM (rat); Native P2Y2-like receptor: IC50 = ~ 0.9 mM; Recombinant P2Y4 receptors: IC50 = ~ 15 mM
Safety and Reference Information
PubChem CID:50937405
MDL Number:MFCD00153865
SMILES:CC1=NC(=NNC2=C(C=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])C(=C(C1=O)C=O)COP(=O)([O -])[O-].[Na+].[Na+].[Na+].[Na+]
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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Lambrecht et al (1992) PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur.J.Pharmacol. 217 217. McLaren et al (1994) Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens. Br.J.Pharmacol. 111 913. Ziganshin et al (1994) Selective antagonism by PPADS at P2x-purinoceptors in rabbit isolated blood vessels. Br.J.Pharmacol. 111 93. Ralevic and Burnstock (1998) Receptors for purines and pyrimidines. Pharmacol.Rev. 50 413.
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