Molecular structure of Physostigmine, CAS Number: 57-47-6
Physostigmine (CAS 57-47-6)
See product citations (5)
Alternate Names:
Physostigmine is also known as Antilirium.
Application:
Physostigmine is a reversible cholinesterase inhibitor and highly toxic parasympathomimetic alkaloid.
CAS Number:
57-47-6
Purity:
≥98%
Molecular Weight:
275.35
Molecular Formula:
C15H21N3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Physostigmine is an alkaloid. Physostigmine is noted to act as a potent and reversible inhibitor of cholinesterase. The inhibition of acetylcholinesterase by physostigmine results in an increase in the concentration of acetylcholine at nerve endings and synapses. This biochemical activity allows for a prolonged interaction of acetylcholine with its receptors, enhancing cholinergic transmission. Physostigmine is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE). Physostigmine has been used as a positive control in a study investigating acetylcholinesterase inhibitors.
Physostigmine (CAS 57-47-6) References
- Transdermal delivery of physostigmine: effects of enhancers and pressure-sensitive adhesives. | Kim, JH., et al. 2002. Drug Dev Ind Pharm. 28: 833-9. PMID: 12236069
- Physostigmine analogs anticholinesterases: effects of the lengthening of the N-carbamic chain on the inhibition kinetics. | Marta, M., et al. 1992. Biochim Biophys Acta. 1120: 262-6. PMID: 1576152
- Activation and block of the adult muscle-type nicotinic receptor by physostigmine: single-channel studies. | Militante, J., et al. 2008. Mol Pharmacol. 74: 764-76. PMID: 18523135
- Ligand-based 3D-QSAR studies of physostigmine analogues as acetylcholinesterase inhibitors. | Ul-Haq, Z., et al. 2009. Chem Biol Drug Des. 74: 571-81. PMID: 19843075
- Effects of subcutaneous and intracerebroventricular injection of physostigmine on the acute corneal nociception in rats. | Tamaddonfard, E. and Hamzeh-Gooshchi, N. 2010. Pharmacol Rep. 62: 858-63. PMID: 21098868
- Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice. | Kalogiannis, M., et al. 2011. PLoS One. 6: e18697. PMID: 21533254
- Anticholinesterasic, nematostatic and anthelmintic activities of pyridinic and pyrazinic compounds. | Valli, M., et al. 2011. Curr Med Chem. 18: 3423-30. PMID: 21728957
- Physostigmine and recent memory: effects in young and aged nonhuman primates. | Bartus, RT. 1979. Science. 206: 1087-9. PMID: 227061
- Prevention of physostigmine-induced lethality in rats. A pharmacological analysis. | Niemegeers, CJ., et al. 1982. Arch Int Pharmacodyn Ther. 259: 153-65. PMID: 6129832
- Immediate effects of physostigmine on amitryptyline-induced QRS prolongation. | Goldberger, AL. and Curtis, GP. 1982. J Toxicol Clin Toxicol. 19: 445-54. PMID: 7175989
- The inhibition and protection of cholinesterase by physostigmine and pyridostigmine against Soman poisoning in vivo. | Xia, DY., et al. 1981. Fundam Appl Toxicol. 1: 217-21. PMID: 7184786
- Transdermal delivery of physostigmine. A pretreatment against organophosphate poisoning. | Jenner, J., et al. 1995. J Pharm Pharmacol. 47: 206-12. PMID: 7602482
- Toxicology reviews: physostigmine. | Shannon, M. 1998. Pediatr Emerg Care. 14: 224-6. PMID: 9655671
Inhibitor of:
AChE, BChE, Ces1d, Ces2g, Ces3a, CHAC1, Choactase, CHT1, and COLQ.Activator of:
AChRα1, AChRα9, AChRδ, Ces3a, CPM, Ly-6F, Ly-6I, and Lynx1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Physostigmine, 5 mg | sc-202764 | 5 mg | $363.00 |