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Olomoucine II (CAS 500735-47-7)

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Synonym:6-(2-Hydroxybenzylamino)-2(R)-[[1-hydroxymethyl)propyl]amino]-9-isopropylpurine
Application:A selective inhibitor of CDK1/cyclin B and a potent cytotoxin in tumor cell lines
CAS Number:500735-47-7
Purity:≥98%
Molecular Weight:370.45
Molecular Formula:C19H26N6O2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Olomoucine II sc-202750 1 mg $30
Olomoucine II sc-202750A 5 mg $99
Description
Olomoucine II is a selective inhibitor of Cdk1(CDK1)/cyclin B (IC50 = 20 nM). Olomoucine II is a potent cytotoxin in tumor cells: IC50 = 5.3 μM against MCF7 cells, IC50 = 11.1 μM against K562 cells, IC50 = 3.0 μM against CEM cells, IC50 = 6.3 μM against HOS cells, and IC50 = 6.3 μM against G361 cells.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO, DMF, 100% ethanol, and chloroform (50 mg/ml).
Storage:Store at -20° C
Melting Point:254.54 °C (Predicted)
Boiling Point:618.47 °C at 760 mmHg (Predicted)
Density:1.33 g/cm3 (Predicted)
Refractive Index:n20D 1.66 (Predicted)
IC50:Cdc2/cyclin B: IC50 = 20 nM; CEM cells: IC50 = 3.0 µM; MCF7 cells: IC50 = 5.3 µM; HOS cells: IC50 = 6.3 µM; G361 cells: IC50 = 6.3 µM; K562 cells: IC50 = 11.1 µM
Safety and Reference Information
WGK Germany:3
PubChem CID:10067756
MDL Number:MFCD06411574
SMILES:CCC(CO)NC1=NC2=C(C(=N1)NCC3=CC=CC=C3O)N=CN2C(C)C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Krystof, V., et al. 2002. Bioorg. Med. Chem. Lett. 12: 3283-3286. PMID: 12392733
2. Krystof, V., et al. 2005. Cell Mol. Life Sci. 62: 1763-1771. PMID: 16003486
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