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Monosodium urate (crystals) (CAS 1198-77-2)

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Synonym:Uric Acid (crystals)
Application:A Cryopyrin inflammatory compound that induces IL-1β production
CAS Number:1198-77-2
Molecular Weight:190.1
Molecular Formula:C5H3N4O3•Na
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Monosodium urate (crystals) sc-202711 2 mg $82
Description
Monosodium urate has been reported to be an inflammatory compound. Mechanistic studies suggest that this compound intracellularly engages caspase-1-activating cryopyrin inflammasome, resulting in the production of active IL-1β and IL-18. Experiments have shown that monosodium urate crystals also induce triggering receptor expressed on myeloid cells 1 (TREM-1) expression in infiltrating leukocytes in a murine air-pouch model of crystal-induced acute inflammation. Monosodium urate is also an activator of cryopyrin.
Usage
Solution may appear as a slightly hazy suspension.
Technical Information
Appearance:Crystalline
Physical State:Solid
Solubility:Soluble in 1M NaOH (25 mg/ml), and PBS.
Storage:Store at -20° C
Refractive Index:n20D ~1.72 (Predicted)
Safety and Reference Information
WGK Germany:3
RTECS:YU7062000
PubChem CID:16220071
MDL Number:MFCD00067310
EC Number:214-838-1
SMILES:C12=C(NC(=O)N1)NC(=O)NC2=O.[Na]
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Murakami, Y., et al. 2006. Arthritis Rheum. 54: 455-462. PMID: 16447220
2. Martinon, F., et al. 2006. Nature. 440: 237-241. PMID: 16407889
3. Giamarellos-Bourboulis, E.J., et al. 2009. Ann. Rheum. Dis. 68: 273-278. PMID: 18390571
4. Hoffman, H.M., et al. 2010. Arthritis Rheum. 62: 2170-2179. PMID: 20506351
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