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Kanamycin B sulfate (CAS 29701-07-3)

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Synonym:Bekanamycinsulfate salt
Application:Highly potent antibiotic against gram-negative bacteria often used in cell culture
CAS Number:29701-07-3
Purity:≥95%
Molecular Weight:581.59
Molecular Formula:C18H37N5O10•H2SO4
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Kanamycin B sulfate sc-202680 250 mg $55
Description
Kanamycin B is an aminoglycoside with antibiotic properties that associates with bacterial ribosomal RNA. The compound is highly potent against gram-negative bacteria. Other members of the aminoglycoside group include Kanamycin A (sc-205358) and Amikacin (sc-202457). Kanamycin B has five amino groups and has a stronger association with acidic phospholipids in comparison to Kanamycin A. Studies have shown that the Kcat value of the kanamycin group is higher compared to the neomycin group.
Technical Information
Appearance:Crystalline powder
Physical State:Solid
Derived from:Streptomyces kanamyceticus
Solubility:Soluble in water (50 mg/ml), and aqueous solution (92.3 mg/ml).
Storage:Store at -20° C
Boiling Point:807.7 °C at 760 mmHg (Predicted)
Refractive Index:n20D 1.67 (Predicted)
IC50:Bacillus subtilis: IC50 = 0.39 ug.mL-1; Staphylococcus aureus: IC50 = 1.56 ug.mL-1; Mycobacterium tuberculosis: IC50 = 2.5 ug.mL-1; Escherichia coli: IC50 = 3.13 ug.mL-1; Pseudomonas aeruginosa: IC50 = 3.13 ug.mL-1
Safety and Reference Information
RTECS:WK1976500
PubChem CID:169075
Merck Index:14: 5281
EC Number:225-170-5
SMILES:C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO )O)N)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)N)N.[O-]S(=O)(=O)[O-]
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Basak, K. and Majumdar, S.K. 1973. Antimicrob. Agents Chemother. 4: 6-10. PMID: 4791483
2. Yung, M.W. and Green, C. 1987. J. Antibiot. 40: 862-867. PMID: 3610836
3. Carrier, D., et al. 1997. Biochem. Pharmacol. 53: 401-408. PMID: 9065744
4. Kwon, M., et al. 2001. Mol. Cells. 11: 303-311. PMID: 11459219
5. Norris, A.L., et al. 2010. Biochemistry. 49: 4027-4035. PMID: 20387903
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Certificate of Analysis

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