Indirubin-3'-monoxime (CAS 160807-49-8)

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Application:	A potent inhibitor of GSK-3β, Cdk1, and Cdk5
CAS Number:	160807-49-8
Purity:	98%
Molecular Weight:	277.3
Molecular Formula:	C₁₆H₁₁N₃O₂

Ordering Information

Product Name	Catalog #	Unit	Price
Indirubin-3'-monoxime	sc-202660	1 mg	$75
Indirubin-3'-monoxime	sc-202660A	5 mg	$250
Indirubin-3'-monoxime	sc-202660B	50 mg	$600

Description

Indirubin-3'-monoxime is a potent inhibitor of GSK-3β (IC₅₀=22 nM)1. Indirubin-3'-monoxime also inhibits CDK1 (p34cdc2; IC₅₀=180 nM) and CDK5 (IC₅₀=100 nM)1. Indirubin-3'-monoxime reversibly arrests asynchronous HBL-100 cells at G22. This compound induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM).

Technical Information

Appearance:	Dark red
Physical State:	Solid
Solubility:	Soluble in DMSO (6 mg/ml), ethanol (4 mg/ml), DMF (~10 mg/ml), 1:5 DMSO:PBS (pH 7.2) (0.15 mg/ml), and methanol. Insoluble in water.
Storage:	Store at -20° C
Melting Point:	247-249 °C
Boiling Point:	645.5 °C at 760 mmHg (Predicted)
Density:	1.5 g/cm³
Refractive Index:	n²⁰_D 1.77
IC50:	GSK-3β: IC₅₀ = 22 nM; Cdk1: IC₅₀ = 180 nM; Cdk5: IC₅₀ = 100 nM; CDK2/cyclin A: IC₅₀ = ~500 nM; CDK4/cyclin D1: IC₅₀ = 3.3 µM

Safety and Reference Information

WGK Germany:	3
PubChem CID:	5326739
SMILES:	C1=CC=C2C(=C1)C(=C(N2)C3=C4C=CC=CC4=NC3=O)NO

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Leclerc, S., et al. 2001. J. Biol. Chem. 276: 251-260. PMID: 11013232
11161389

SDS

Datasheet/SDS