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Indirubin-3'-monoxime (CAS 160807-49-8)

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Synonym:Indirubin-3’-oxime 3-[1,3-Dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Application:A potent inhibitor of GSK-3β, Cdk1, and Cdk5
CAS Number:160807-49-8
Purity:98%
Molecular Weight:277.30
Molecular Formula:C16H11N3O2
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Indirubin-3'-monoxime sc-202660 1 mg $75
Indirubin-3'-monoxime sc-202660A 5 mg $309
Indirubin-3'-monoxime sc-202660B 50 mg $645
Description
Indirubin-3'-monoxime is a potent inhibitor of GSK-3β (IC50=22 nM)1. Indirubin-3'-monoxime also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM)1. Indirubin-3'-monoxime reversibly arrests asynchronous HBL-100 cells at G22. This compound induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM). Indirubin-3'-monoxime is an inhibitor of Cdk2, cyclin A, cyclin B, cyclin E and p35.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (6 mg/ml), ethanol (4 mg/ml), DMF (~10 mg/ml), 1:5 DMSO:PBS (pH 7.2) (0.15 mg/ml), and methanol. Insoluble in water.
Storage:Store at -20° C
Melting Point:247-249 °C
Boiling Point:645.5 °C at 760 mmHg (Predicted)
Density:1.5 g/cm3
Refractive Index:n20D 1.77
IC50:GSK-3β: IC50 = 22 nM; Cdk1: IC50 = 180 nM; Cdk5: IC50 = 100 nM; CDK2/cyclin A: IC50 = ~500 nM; CDK4/cyclin D1: IC50 = 3.3 µM
Safety and Reference Information
WGK Germany:3
PubChem CID:5326739
MDL Number:MFCD02683594
SMILES:C1=CC=C2C(=C1)C(=C(N2)C3=C4C=CC=CC4=NC3=O)NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Leclerc, S., et al. 2001. J. Biol. Chem. 276: 251-260. PMID: 11013232
11161389
SDS
Certificate of Analysis

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