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Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt (CAS 94825-44-2)

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Synonym:GTP-γ-S 4Li
Application:A G-protein-activating GTP analog
CAS Number:94825-44-2
Molecular Weight:562.98
Molecular Formula:C10H12N5O13P3S•4Li
Refer to Certificate of Analysis for lot specific data (including water content).
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Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt sc-202639 10 mg $278
Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt is a Gβ-activating (G-protein-activating) GTP analog, which is more resistant to hydrolysis than GTP. Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.
Technical Information
Physical State:Solid
Solubility:Soluble in water (≥75 mg/ml).
Storage:Store at -20° C
Refractive Index:n20D 1.95 (Predicted)
Ki Data:Kappa opioid receptor: Ki= 0.0048 nM (human)
pK Values:pKa: 0.97 (Predicted), pKb: 2.42 (Predicted)
Safety and Reference Information
WGK Germany:3
PubChem CID:44134755
MDL Number:MFCD00135151
EC Number:305-606-1
Beilstein Registry:8182249
SMILES:[Li+].[Li+].[Li+].[Li+].NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(= O)OP([O-])([O-])=S)[C@@H](O)[C@H]2O)C(=O)N1
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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1.Lino, S., et al. 2000. FEBS Lett. 479, 46. 2.Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182. 3.Hess, S.D., et al. 1993. Science 259, 1169. 4.Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183. 5.McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117. Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66. 6.Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466. 7.Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615. 8.Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.
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