Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt (CAS 94825-44-2)

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Application:	A G-protein-activating GTP analog
CAS Number:	94825-44-2
Molecular Weight:	563.0
Molecular Formula:	C₁₀H₁₂N₅O₁₃P₃S 4Li

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Description

Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt is a Gβ-activating (G-protein-activating) GTP analog, which is more resistant to hydrolysis than GTP. Guanosine 5'-O-(3-thiotriphosphate) tetralithium salt induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.

Technical Information

Appearance:	White
Physical State:	Solid
Solubility:	Soluble in water (≥75 mg/ml).
Storage:	Store at -20° C
Refractive Index:	n²⁰_D 1.95 (Predicted)

Safety and Reference Information

Transport:	UN 3335, Class 9, Packing group n/a
WGK Germany:	3
PubChem CID:	44134755
MDL Number:	MFCD00135151
EC Number:	305-606-1
Beilstein Registry:	8182249
SMILES:	[Li+].[Li+].[Li+].[Li+].NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(= O)OP([O-])([O-])=S)[C@@H](O)[C@H]2O)C(=O)N1

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1.Lino, S., et al. 2000. FEBS Lett. 479, 46. 2.Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182. 3.Hess, S.D., et al. 1993. Science 259, 1169. 4.Ekstrom, R.C., et al. 1992. J. Biol. Chem. 267, 22183. 5.McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci. 49, 117. Vaca, L., et al. 1992. Eur. J. Physiol. 422, 66. 6.Silk, S.T., et al. 1989. J. Biol. Chem. 264, 21466. 7.Gilman, A.G. 1987. Annu. Rev. Biochem. 56, 615. 8.Orellana, S., et al. 1987. J. Biol. Chem.. 262, 1638.

SDS

Datasheet/SDS