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CMP-Sialic Acid, Disodium Salt (CAS 3063-71-6)

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Synonym:CMP-N-Acetylneuraminic Acid, 2Na CMP-NANA CMP-Neu5Ac CMP-NAN CMP-Sialic acid
Application:A toxin/glycoprotein/gonococci protector; blood regulator
CAS Number:3063-71-6
Purity:≥85%
Molecular Weight:658.4
Molecular Formula:C20H29N4O16P 2Na
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
CMP-Sialic Acid, Disodium Salt sc-202549 1 mg $56
CMP-Sialic Acid, Disodium Salt sc-202549A 5 mg $214
Description
CMP-sialic acid, Disodium salt is the active form of sialic acid. In mammalian cells it has been shown to be required for the biosynthesis of sialic acid-containing complex carbohydrates. Loss of CMP sialic acid, Disodium salt production or the feed back inhibitor of CMP-sialic acid has lead to gram scale production of sialic acid by GLCNE (GNE, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase). The compound has demonstrated the ability to neutralize various toxins through masking binding sites. CMP-sialic acid, Disodium salt has also provided protection against gonococci by siaylation of Gal beta 1-4GlcNAc group. Catalyzed through a surface sialyl-transferase, CMP-Sialic Acid, Disodium Salt enhanced the responsiveness of insulin. The compound has also displayed function in blood protein half-life regulation, protection against glycoprotein lysis and cellular adhesion.
Technical Information
Appearance:White to off-white lyophilized solid
Physical State:Solid
Solubility:Soluble in water.
Storage:Store at -20° C
Safety and Reference Information
MDL Number:MFCD00151579
SMILES:[Na+].CC(=O)N[C@@H]1[C@@H](O)C[C@](OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H] 2O)N2C=CC(N)=NC2=O)(OC1[C@H](O)[C@H](O)CO)C(O)=O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Gottlieb, C. and Kornfeld, S. 1976. J. Biol. Chem. 251: 7761-7768. PMID: 1002711
2. Salhanick, A.I. and Amatruda, J.M. 1988. Am. J. Physiol. 255: E173-E179. PMID: 3407769
3. Parsons, N.J., et al. 1994. Microb. Pathog. 16: 413-421. PMID: 7830528
4. Bork, K., et al. 2005. FEBS Lett. 579: 5079-5083. PMID: 16137682
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