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Closantel (CAS 57808-65-8)

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Application:Potentially useful for studying P-glycoprotein interactions in vitro
CAS Number:57808-65-8
Purity:≥98%
Molecular Weight:663.1
Molecular Formula:C22H14Cl2I2N2O2
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Closantel sc-202548 200 mg $96
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Description
Closantel is an antihelmintic agent and a potentially useful compound for studying P-glycoprotein interactions in vitro
Technical Information
Physical State:Solid
Solubility:Insoluble in water.
Storage:Store at 4° C
Melting Point:218-223 °C
Boiling Point:590.52 °C at 760 mmHg (Predicted)
Density:1.94 g/cm3 (Predicted)
Refractive Index:n20D 1.74 (Predicted)
IC50:TXA synthase: IC50 = 64 nM (human); Adenosine A3-R: IC50 = 96 nM (human); EGFR: IC50 = 564 nM (human); p38α: IC50 = 656 nM (human); Fyn: IC50 = 939 nM (human)
Ki Data:Adenosine A3-R: Ki= 54 nM (human); Chitinase: Ki= 468 nM (Onchocerca volvulus); α2B-AR: Ki= 821.9 nM (human); α2C-AR: Ki= 1 µM (human); DAT: Ki= 3.8 µM (human)
pK Values:pKa: 5.99 (Predicted)
Safety and Reference Information
Transport:UN 2811, Class 6.1, Packing group III
WGK Germany:3
RTECS:CV2444250
PubChem CID:42574
Merck Index:14: 2411
MDL Number:MFCD00661151
EC Number:260-967-1
SMILES:CC1=C(NC(=O)C2=C(O)C(I)=CC(I)=C2)C=C(Cl)C(=C1)C(C#N)C1=CC=C(Cl)C=C1
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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