Molecular structure of Australine hydrochloride, CAS Number: 186766-07-4
Australine hydrochloride (CAS 186766-07-4)
See product citations (1)
Alternate Names:
(1R,2R,3R,7S,7aR)-3-Hydroxymethyl-1,2,7-trihydroxypyrrolizidine HCI, 7.alpha.-Epialexine
Application:
Australine hydrochloride is a pyrrolizidine inhibitor of glucosidase
CAS Number:
186766-07-4
Purity:
≥95%
Molecular Weight:
225.67
Molecular Formula:
C8H15NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Australine hydrochloride is a polyhydroxylated pyrrolizidine alkaloid that inhibits a-glucosidase, amyloglucosidase, and glucosidase I. Australine hydrochloride appears to be the first glucosidase inhibitor that is active toward glucosidase I but not glucosidase II. Inhibits glycoprotein processing at the gucosidase I step, resulting in the accumulation of glycoproteins containing Glc3Man7-9(GlcNAc)2-oligosaccharides. Does not inhibit alpha- or beta-galactosidase, beta-glucosidase, or alpha- or beta-mannosidase.
Australine hydrochloride (CAS 186766-07-4) References
- Synthesis and biological activity of naturally occurring α-glucosidase inhibitors. | Wardrop, DJ. and Waidyarachchi, SL. 2010. Nat Prod Rep. 27: 1431-68. PMID: 20714463
- Purification to homogeneity and properties of glucosidase II from mung bean seedlings and suspension-cultured soybean cells. | Kaushal, GP., et al. 1990. J Biol Chem. 265: 16271-9. PMID: 2168886
- Australine, a pyrrolizidine alkaloid that inhibits amyloglucosidase and glycoprotein processing. | Tropea, JE., et al. 1989. Biochemistry. 28: 2027-34. PMID: 2497772
- Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues. | Paparella, AS., et al. 2021. Nat Commun. 12: 6285. PMID: 34725358
- Calystegins, a novel class of alkaloid glycosidase inhibitors. | Molyneux, RJ., et al. 1993. Arch Biochem Biophys. 304: 81-8. PMID: 8323301
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Australine hydrochloride, 1 mg | sc-202479 | 1 mg | $312.00 |