Aloisine A has been noted as an inhibitor of cyclin-depedent kinases (CDKs). CDKs have been shown to regulate the cell cycle, neuronal functions, transcription, apoptosis, and exocytosis. Mechanistic studies suggest that Aloisine A competitively inhibits binding of ATP to catalytic subunit of the CDKs. This compound has also displayed anti-proliferative properties by causing cell growth arrest at the G1 and G2.
