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- Stauprimide, Molecular Formula: C35H28N4O5, Molecular Weight: 584.6 g/mol, CAS: 154589-96-5
- 500 µg
- Stauprimide is a semi-synthetic analogue of the staurosporine family of indolocarbazoles. Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as a potential antitumor agent. More recently, stauprimide has been shown to increase the efficiency of the directed differentiation of mouse and human embyronic stem cells in synergy
with defined extracellular signalling cues. Stauprimide interacts with NME2 (PUF) transcription factor to down-regulate c-Myc expression, leading to differentiation of stem cells.
- >95%
- Soluble in methanol, ethanol, DMF or DMSO
- Yellow orange solid
- 1. Inhibitory activity and selectivity of staurosporine derivatives towards protein kinase C. Caravatti G. et
al., Bioorg. Med. Chem. Letters 1994, 4, 399.
2. A small molecule primes embryonic stem cells for differentiation. Zhu S. et al., Cell Stem Cell 2009, 4,
416
- For Research Use Only
- SMILES: CO[C@@H]1[C@@H](C[C@H]2O[C@@]1(C)n1c3ccccc3c3c4c(=
O)[nH]c(=O)c4c4c5ccccc5n2 c4c13)N(C)C(=O)c1ccccc1
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Stauprimide
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