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Stauprimide: sc-202346

 |  Datasheet  | MSDS
  • Specifications
    • Offered as 500 µg (sc-202346)
    • CAS Number: 154589-96-5
    • Molecular Weight: 584.6
    • Molecular Formula: C35H28N4O5
    • Purity: >95%
    • Derived from: Streptomyces
    • Physical Appearance: Yellow orange solid
    • Solubility: Soluble in methanol, ethanol, DMF or DMSO
    • SMILES: CO[C@@H]1[C@@H](C[C@H]2O[C@@]1(C)n1c3ccccc3c3c4c(=
      O)[nH]c(=O)c4c4c5ccccc5n2 c4c13)N(C)C(=O)c1ccccc1
  • Description
    • Stauprimide is an indolocarbazole semi-synthetic small molecule shown to significantly increase the efficiency of directed embryonic stem cell differentiation. Stauprimide inhibits the nuclear localization of NME2, blocking and downregulating c-Myc expression. The expression of c-Myc is crucial for embryonic stem cell self-renewal, and intervention by Stauprimide allows for more efficient lineage-specific differentiation. NME2 is also indicated to be upregulated in certain cancers, indicating further application for the blocking action of Stauprimide.
  • Storage
    • Store at -20° C
  • For Research Use Only
  • References
    • 1. Zhu, S., et al. 2009. Cell Stem Cell. 4: 416-426. PMID: 19427291
 
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Product NameCatalog #UnitPriceQtyAddFavorites
Stauprimide sc-202346 500 µg $473
Stauprimide
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Stauprimide
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