p-Integrin β3 Antibody (Tyr 747): sc-20234

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Integrins are heterodimers composed of noncovalently associated transmembrane a and b subunits. The 16 å and 8 ∫ subunits heterodimerize to produce more than 20 different receptors (1,2). Most integrin receptors bind ligands that are components of the extracellular matrix, but can also bind to soluble ligands or to counterreceptors on adjacent cells, thereby leading to aggregation of cells (2). Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors (3). In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis (4,5). GRB2 binds Integrin ∫3 only when both Tyr 747 and Tyr 759 are phosphorylated (6). However, SHC binds the monophosphorylated Integrin ∫3 at Tyr 759, suggesting that tyrosine phosphorylation of Integrin ∫3 may be important in intiating outside-in signaling cascades by inducing association of signaling components directly with Integrin (6).