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Roquefortine C (CAS 58735-64-1)

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Application:A potent neurotoxin produced most notably by Penicillium species
CAS Number:58735-64-1
Purity:>99%
Molecular Weight:389.5
Molecular Formula:C22H23N5O2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Roquefortine C sc-202323 500 µg $370
Description
Roquefortine C is a mycotoxin produced by Penicillium roqueforti and P. crustosum. This compound has been noted to cause serious toxic effects in cell lines. In some experiments, Roquefortine C has been used as a biomarker for penitrem A intoxication. Studies suggest that G protein-mediated signaling is a key component of Roquefortine C production by Penicillium roqueforti. Further experiments report that Roquefortine C is potentially a neurotoxic compound that activates and inhibits detoxification enzymes Mdr (P-glycoprotein, P-gp) and CYP (cytochrome P450-3A), respectively.
Technical Information
Physical State:Solid
Derived from:Unidentified fungus
Solubility:Soluble in 100% ethanol, methanol (10 mg/ml), DMSO (10 mg/ml), DMF, and water (poor).
Storage:Store at -20° C
Melting Point:303.10 °C (Predicted)
Boiling Point:768.27 °C at 760 mmHg (Predicted)
Density:1.37 g/cm3 (Predicted)
Refractive Index:n20D 1.69 (Predicted)
Safety and Reference Information
WGK Germany:3
RTECS:UQ4730500
PubChem CID:6436831
MDL Number:MFCD22416530
SMILES:CC(C)(C=C)C12CC3C(=O)NC(=CC4=CN=CN4)C(=O)N3C1NC5=CC=CC=C25
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Keblys, M., et al. 2004. Mycopathologia. 158: 317-324. PMID: 15702270
2. Bünger, J., et al. 2004. Toxicology. 202: 199-211. PMID: 15337583
3. Aninat, C., et al. 2005. Food Addit Contam. 22: 361-368. PMID: 16019806
4. García-Rico, R.O., et al. 2009. Int. Microbiol. 12: 123-129. PMID: 19784932
5. Tiwary, A.K., et al. 2009. J. Vet. Diagn. Invest. 21: 237-239. PMID: 19286504
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