Rocaglamide AL (CAS 201212-33-1)

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Synonym:	3’-4’-Methylenedioxyrocaglamide
Application:	A derivative of rocaglamide with selective cytotoxic effects
CAS Number:	201212-33-1
Purity:	≥97%
Molecular Weight:	448.5
Molecular Formula:	C₂₆H₂₄O₇

Description

Rocaglamides are potent phytochemicals that suppress IFN-γ, TNFα, IL-2, and IL-4 production in peripheral blood T cells at nanomolar concentrations. Studies show that rocaglamides derivatives are effective in inducing the mitochondrial apoptosis pathway in various cancer cell lines and exhibit selective cytotoxic effects. Rocaglamides are members of the cyclopenta ∫ benzofuran group of natural compounds extracted from the plant genus Aglaia. The Algaia plants are used in traditional medicine for the treatment of inflammatory skin diseases and allergic inflammatory disorders such as asthma.

Technical Information

Appearance:	White to off-white sticky solid
Physical State:	Solid
Derived from:	Aglaia sp.
Solubility:	Soluble in DMSO or 100% ethanol
Storage:	Store at -20° C

Safety and Reference Information

SMILES:

COc1cc(OC)c2c(c1)O[C@]1(c3ccc4OCOc4c3)[C@@H](C[C@@H](O)[C@]21O)c1ccccc1

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Schneider, C., et al. 2000. Phytochemistry. 54: 731-736. PMID: 11014256
2. Chaidir, W.H., et al. 2001. J. Nat. Prod. 64: 1216-1220. PMID: 11575959
3. Baumann, B., et al. 2002. J. Biol. Chem. 277: 44791-44800. PMID: 12237314
4. Proksch, P., et al. 2005. J. Immunol. 174: 7075-7084. PMID: 15905551
5. Kim, S., et al. 2006. Anticancer Agents Med Chem. 6: 319-345. PMID: 16842234
6. Chumkaew, P., et al. 2006. Chem. Pharm. Bull. 54: 1344-1346. PMID: 16946551
7. Zhu, J.Y., et al. 2007. Int. J. Cancer. 121: 1839-1846. PMID: 17565740
8. Zhu, J.Y. , et al. 2009. Cell Death Differ. 16: 1289-1299. PMID: 19373244

SDS

Datasheet/SDS