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Pseurotin A (CAS 58523-30-1)

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Application:A fungal metabolite neurite formation promoter and IgE suppressor
CAS Number:58523-30-1
Purity:>99%
Molecular Weight:431.5
Molecular Formula:C22H25NO8
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Pseurotin A sc-202300 1 mg $195
Description
Pseurotin A is a heterospirocyclic secondary metabolite natural product originally isolated from the culture broth of Pseudeurotium ovalis. Pseurotin A was identified as a competitive inhibitor of chitin synthase. Pseurotin A was found to induce cell differentiation of PC12 neuronal cells, indicating the compound as a tool for studying the mechanism of neurite formation. The production of immunoglobulin E (IgE) is suppressed by Pseurotin A, suggesting use as an interventional tool for studies of IgE-mediated systemic allergic response mechanisms.
Technical Information
Appearance:White
Physical State:Solid
Derived from:Aspergillus fumigatus
Solubility:Soluble in ethanol, methanol, DMF or DMSO.
Storage:Store at -20° C
Safety and Reference Information
PubChem CID:6438510
SMILES:CCC=CC(C(C1=C(C(=O)C2(O1)C(C(NC2=O)(C(=O)C3=CC=CC=C3)OC)O)C)O)O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Komagata, D., et al. 1996. J. Antibiot. 49: 958-959. PMID: 8931737
2. Hayashi, Y., et al. 2003. Org. Lett. 5: 2287-2290. PMID: 12816430
3. Ishikawa, M., et al. 2009. Bioorg. Med. Chem. Lett. 19: 1457-1460. PMID: 19179074
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