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N9-Isopropyl-olomoucine (CAS 158982-15-1)

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Application:An inhibitor of CDK1/cyclin B and CDK5/p35
CAS Number:158982-15-1
Purity:≥98%
Molecular Weight:326.4
Molecular Formula:C17H22N6O
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
N9-Isopropyl-olomoucine sc-202264 1 mg $152
N9-Isopropyl-olomoucine sc-202264A 5 mg $555
Description
N9-Isopropyl-olomoucine is an inhibitor of CDK1/cyclin B (IC50 = 2 μM) and CDK5/p35 (IC50 = 3 μM).
Technical Information
Appearance:Crystalline
Physical State:Solid
Solubility:Soluble in DMSO, DMF, and methanol (sparingly).
Storage:Store at -20° C
Melting Point:230.70 °C (Predicted)
Boiling Point:574.87 °C at 760 mmHg (Predicted)
Density:1.30 g/cm3 (Predicted)
Refractive Index:n20D 1.66 (Predicted)
IC50:CDK1/cyclin B: IC50 = 2 µM; CDK5/p35: IC50 = 3 µM; Cdk2: IC50 = 8 µM
Ki Data:Cdk5: Ki= 1.26 µM (human); CLK2: Ki= 1.58 µM (human); Cdk2: Ki= 1.58 µM (human); HIPK4: Ki= 2.00 µM (human); CLK4: Ki= 2.5 µM (human)
pK Values:pKb: 4.76 (Predicted)
Safety and Reference Information
WGK Germany:3
PubChem CID:6610355
MDL Number:MFCD01310377
SMILES:CC(C)N1C=NC2=C1N=C(N=C2NCC3=CC=CC=C3)NCCO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Vesely, J., et al. 1994. Eur. J. Biochem. 224: 771-786. PMID: 7925396
2. Raynaud, F.I., et al. 2004. Mol. Cancer Ther. 3: 353-362. PMID: 15026556
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