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N-Acetyltryptamine (CAS 1016-47-3)

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Synonym:3-(2-N-Acetylaminoethyl)indole
Application:A partial agonist for melatonin receptors in the retina
CAS Number:1016-47-3
Molecular Weight:202.25
Molecular Formula:C12H14N2O
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
N-Acetyltryptamine sc-202233 10 mg $105
N-Acetyltryptamine sc-202233A 50 mg $409
Description
N-Acetyltryptamine is a partial agonist of the melatonin receptors. N-Acetyltryptamine bears a reduced structure of Melatonin (sc-207848), lacking the 5-methoxy group. N-Acetyltryptamine is described to demonstrate agonism at melatonin receptors in the rabbit retina, inhibiting Ca2+-dependent release of [3H]dopamine. N-Acetyltryptamine is also described to demonstrate competitive antagonism of the inhibitory effect of melatonin on [3H]dopamine release in the chicken retina.
Technical Information
Appearance:Powder
Physical State:Solid
Solubility:Soluble in alcohol, methanol (50 mg/ml), ethanol (100 mM), and DMSO (100 mM).
Storage:Store at 4° C
Melting Point:64 °C
Boiling Point:~484.7 °C at 760 mmHg (Predicted)
Density:~1.2 g/cm3 (Predicted)
Refractive Index:n20D 1.62 (Predicted)
Ki Data:Melatonin receptor: Ki= 0.70 µM (Gallus gallus)
Safety and Reference Information
WGK Germany:3
PubChem CID:70547
MDL Number:MFCD00209910
Beilstein Registry:170780
SMILES:CC(=O)NCCC1=CNC2=CC=CC=C21
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Dubocovich, M.L. 1985. J. Pharmacol. Exp. Ther. 234: 395-401. PMID: 2991499
2. Dubocovich, M.L. 1988. J. Pharmacol. Exp. Ther. 246: 902-910. PMID: 2843633
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