 |
- Specifications
- Offered as 10 mg (sc-202231) and 25 mg (sc-202231A) sizes
- CAS Number: 151767-02-1
- Molecular Weight: 608.17
- Molecular Formula: C35H35ClNO3S•Na
- Purity: >99%
- Form: Solid
- Physical Appearance: White to off-white crystalline solid
- Solubility: Soluble in DMSO (100 mg/mL), ethanol (100 mg/mL) and water (40 mg/mL). Buffers, serum, or other additives may increase or decrease the aqueous solubility.
- SMILES: CC(C)(C1=CC=CC=C1CC[C@H](C2=CC=CC(=C2)/C=C/C3=NC4=
C(C=CC(=C4)Cl)C=C3)
SCC5(CC5)CC(=O)[O-])O.[Na+]
- Description
- Montelukast Sodium is a potent, selective, anti-inflammatory CysLT1 receptor antagonist (IC50 < 5nM) with no appreciable affect on the CysLT2 receptor. In rat colitis Montelukast Sodium has demonstrated the ability to increase PGE2 (Prostaglandin E2 - sc-201225) production and lower COX-2 expression. Inhibition is competitive with respect to leukotrienes - particularly LTD4, a biologically active mediator that plays an important role in the control of several biochemical pathways involving pulmonary and immune system function.
- Storage
- Store at -20° C. Compound is unstable in HPLC sample solution at room temperature; HPLC sample must be prepared in ice-cold mobile phase and kept on ice.
- For Research Use Only
- Reference Numbers
- References
- 1. Reiss, T.F., et al. 1998. Arch. Intern. Med. 158: 1213-1220. PMID: 9625400
2. Leff, J.A., et al. 1998. N. Engl. J. Med. 339: 147-152. PMID: 9664090
3. Sarau, H.M., et al. 1999. Mol. Pharmacol. 56: 657-663. PMID: 10462554
4. Lynch, K.R., et al. 1999. Nature. 399: 789-793. PMID: 10391245
5. Heise, C.E., et al. 2000. J. Biol. Chem. 275: 30531-30536. PMID: 10851239
6. Holma, R., et al. 2001. Eur. J. Pharmacol. 429: 309-318. PMID: 11698051
7. Peters-Golden, M., et al. 2005. Ann. Allergy Asthma Immunol. 94: 609-618. PMID: 15984591
|
|
| |
|
|
|
Montelukast Sodium
Click on image to enlarge
|
|
|
Download
|
|
