 |
- Specifications
- Offered as 1 mg (sc-202199)
- Synonym: Methoxybenzene-Sulfonamide
- CAS Number: 139298-40-1
- Molecular Weight: 501.1
- Molecular Formula: C26H29ClN2O4S
- Purity: ≥95%
- Form: Solid
- Physical Appearance: White solid
- Solubility: Soluble in DMSO (25 mg/ml)
- SMILES: CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)
C3=CC=C(C=C3)OC
- Description
- KN-93 is a methoxybenzenesulfonamide that is an effective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylating activity, and the autophosphorylation of the α- and β-subunits of CaMKII. In PC-12h cells, KN-93 has been shown to decrease phosphorylation of KCl and acetylcholine. Data suggest that KN-93 modulates the reaction rate of TH, by reducing the Ca2+ mediated phosphorylation levels of TH, and inhibiting dopamine formation. In rat pancreatic beta cell studies KN-93 was shown to block insulin release, and in prostrate cancer research KN-93 inhibited androgen receptor function and enhanced cell death independent of p53 and Akt. Research indicates that KN-93 induces G1 cell cycle arrest in both HeLa (sc-2200) and NIH 3T3 fibroblast cells (sc-2210), and causes apoptosis in NIH 3T3 cells.
- Storage
- Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
- Usage
- • KN-93 should be dissolved in ethanol first and then diluted with the aqueous buffer of choice, for maximum solubility in aqueous buffers.
• Approximately 0.25 mg/ml of KN-93 can be solubilized in a 1:2 solution of ethanol:PBS (pH 7.2) using this method.
• it is not recommended to store aqueous solution more than one day.
• KN-93 is sparingly soluble in aqueous buffers.
- For Research Use Only
- The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
- Reference Numbers
- PubChem Compound ID: 5312122
- MDL Number: MFCD00236424
- References
- 1. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181: 968-975. PMID: 1662507
2. Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191: 255-261. PMID: 8383489
3. Rasmussen, G., et al. 1995. Biochem. Cell Biol. 73: 201-207. PMID: 7576494
4. Tombes, R.M., et al. 1995. Cell Growth Differ. 6: 1063-1070. PMID: 8519682
5. Rokhlin, O.W., et al. 2010. Cancer Biol. Ther. 9: 224-235. PMID: 20023417
|
|
| |
Product Citations
|
See how others have used KN-93.
6 total citations Loading citations.
|
| |
|
|
|
KN-93
Click on image to enlarge
|
|
|
Download
|
|
