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KN-93 (CAS 139298-40-1)

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Synonym:N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide
Application:An effective inhibitor of CaMKII phosphorylating activity
CAS Number:139298-40-1
Purity:≥95%
Molecular Weight:501.04
Molecular Formula:C26H29ClN2O4S
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
KN-93 sc-202199 1 mg $169
Description
KN-93 is a methoxybenzenesulfonamide that is an effective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) phosphorylating activity, and the autophosphorylation of the α- and β-subunits of CaMKII. In PC-12h cells, KN-93 has been shown to decrease phosphorylation of KCl and acetylcholine. Data suggests that KN-93 modulates the reaction rate of TH by reducing the Ca2+ mediated phosphorylation levels of TH and inhibiting dopamine formation. In rat pancreatic beta cell studies, KN-93 was shown to block insulin release, and in prostrate cancer research, KN-93 inhibited androgen receptor function and enhanced cell death independent of p53 and Akt. Research indicates that KN-93 induces G1 cell cycle arrest in both HeLa (sc-2200) and NIH 3T3 fibroblast cells (sc-2210), and causes apoptosis in NIH 3T3 cells.
Usage
• KN-93 should be dissolved in ethanol first and then diluted with the aqueous buffer of choice, for maximum solubility in aqueous buffers.
• Approximately 0.25 mg/ml of KN-93 can be solubilized in a 1:2 solution of ethanol:PBS (pH 7.2) using this method.
• it is not recommended to store aqueous solution more than one day.
• KN-93 is sparingly soluble in aqueous buffers.
Technical Information
Physical State:Solid
Solubility:Soluble in DMSO (25 mg/ml), water, 1:2 EtOH:PBS(pH 7.2) (~0.25 mg/ml), ethanol (~30 mg/ml), and DMF (~30 mg/ml).
Storage:Store at -20° C
Boiling Point:657.60 °C at 760 mmHg (Predicted)
Density:1.3 g/cm3 (Predicted)
Refractive Index:n20D 1.63
IC50:CaM kinase II: IC50 = 370 nM; histamine-induced aminopyrine uptake: IC50 = 300 nM (parietal cells)
Ki Data:CaM binding to the kinase II: Ki= 370 nM
Safety and Reference Information
WGK Germany:3
PubChem CID:5312122
MDL Number:MFCD00236424
SMILES:CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181: 968-975. PMID: 1662507
2. Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191: 255-261. PMID: 8383489
3. Rasmussen, G., et al. 1995. Biochem. Cell Biol. 73: 201-207. PMID: 7576494
4. Tombes, R.M., et al. 1995. Cell Growth Differ. 6: 1063-1070. PMID: 8519682
5. Rokhlin, O.W., et al. 2010. Cancer Biol. Ther. 9: 224-235. PMID: 20023417
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