Indolmycin (CAS 21200-24-8)

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Synonym:	Antibiotic PA 155A
Application:	An antibiotic that inhibits bacterial tryptophanyl-tRNA synthetase
CAS Number:	21200-24-8
Purity:	>99%
Molecular Weight:	257.3
Molecular Formula:	C₁₄H₁₅N₃O₂

Description

Indolmycin is a naturally occurring antibiotic that acts against Staphylococci and Helicobacter pylori. The compound is a secondary metabolite of Streptomyces griseus with the ability to inhibit bacterial tryptophanyl-tRNA synthetase.

Technical Information

Appearance:	White powder
Physical State:	Solid
Derived from:	Streptomyces sp. MST-AS5532
Solubility:	Soluble in ethanol, methanol, DMF or DMSO.
Storage:	Store at -20° C

Safety and Reference Information

PubChem CID:	3082186
SMILES:	CC(C1C(=O)N=C(O1)NC)C2=CNC3=CC=CC=C32

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Werner, R.G., et al. 1976. Eur. J. Biochem. 68: 1-3. PMID: 786633
2. Bogosian, G., et al. 1983. J. Bacteriol. 153: 1120-1123. PMID: 6337120
3. Hasuoka, A., et al. 2001. Chem. Pharm. Bull. 49: 1604-1608. PMID: 11767081
4. Kitabatake, M., et al. 2002. J. Biol. Chem. 277: 23882-23887. PMID: 11970956
5. Hurdle, J.G., et al. 2004. J. Antimicrob. Chemother. 54: 549-552. PMID: 15243028
6. Vecchione, J.J., et al. 2009. Antimicrob. Agents Chemother. 53: 3972-3980. PMID: 19546369

SDS

Datasheet/SDS