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Hymenidin (CAS 107019-95-4)

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Application:An antagonist of serotonergic receptors and inhibitor of CDK5/p25 and GSK-3β
CAS Number:107019-95-4
Molecular Weight:310.2
Molecular Formula:C11H12BrN5O
Refer to Certificate of Analysis for lot specific data (including water content).
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Hymenidin sc-202177 1 mg $258
Hymenidin is an antagonist of serotonergic receptors and has antiprotozoal activity. Additionally, hymenidin inhibits Cdk5/p35 (IC50 = 4 μM) and GSK-3β (IC50 = 12 μM).
Technical Information
Physical State:Solid
Derived from:Hymeniacidon sp.
Solubility:Soluble in DMSO, and 100 % ethanol.
Storage:Store at -20° C
Melting Point:249.17 °C (Predicted)
Boiling Point:578.30 °C (Predicted)
Density:1.69 g/cm3 (Predicted)
Refractive Index:n20D 1.74 (Predicted)
IC50:Cdk5/p35: IC50 = 4 µM; GSK-3β: IC50 = 12 µM; Plasmodium f.: IC50 = 40.43 µM; Leishmania d.: IC50 = 96.29 µM; Trypanosoma c.: IC50 = 235.65 µM
Safety and Reference Information
PubChem CID:6439099
MDL Number:MFCD08702701
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
1. Kobayashi, J., et al., 1986. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia. 42(10): 1176-7. PMID: 3770140
2. Meijer, L., et al., 2000. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chemistry & biology. 7(1): 51-63. PMID: 10662688
3. Bickmeyer, Ulf., et al., 2004. Brominated pyrrole alkaloids from marine Agelas sponges reduce depolarization-induced cellular calcium elevation. Toxicon : official journal of the International Society on Toxinology. 44(1): 45-51. PMID: 15225561
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