Gilvocarcin M (CAS 77879-89-1)

Application:	The minor analogue of Gilvocarcin V (sc-202170) with anti-bact, -fungal, -viral and -tumor activity
CAS Number:	77879-89-1
Purity:	95% (HPLC)
Molecular Weight:	482.5
Molecular Formula:	C₂₆H₂₆O₉

Description

Gilvocarcin M is the minor analogue of a complex of C-glycoside antitumor actives isolated from Streptomyces. Gilvocarcin M contains a methyl group in the 8-position and is less active than the vinyl analogue Gilvocarcin V (sc-202170), which is thought to act as an inhibitor of human topoisomerase II. Gilvocarcin M displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactivated crosslinkers of DNA to histones.

Technical Information

Appearance:	Yellow
Physical State:	Solid
Derived from:	Streptomyces sp.
Solubility:	Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Storage:	Store at -20° C
Boiling Point:	794.64 °C at 760 mmHg (Predicted)

Safety and Reference Information

PubChem CID:	53801
SMILES:	CC1C(C(C(C(O1)C2=C3C(=C(C=C2)O)C(=CC4=C3OC(=O)C5=CC(=CC(=C54)OC)C)OC)O)O)O

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Nakano, H., et al. 1981. J. Antibiot. 34: 266-270. PMID: 7275807
2. Elespuru, R.K., et al. 1984. Science. 223: 69-71. PMID: 6229029
3. Oyola, R., et al. 1997. Photochem. Photobiol. 65: 802-810. PMID: 9155255
4. Balitz, D.M., et al. 1981. J. Antibiot. 34: 1544-1555. PMID: 7344705
5. Matsumoto, A., et al. 2000. Cancer Res. 60: 3921-3926. PMID: 10919670

SDS

Datasheet/SDS