Molecular structure of Galiellalactone, CAS Number: 133613-71-5
Galiellalactone (CAS 133613-71-5)
See product citations (9)
Application:
Galiellalactone is an inhibitor of IL-6 induced SEAP expression
CAS Number:
133613-71-5
Purity:
>95%
Molecular Weight:
194.22
Molecular Formula:
C11H14O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Galiellalactone is a hexaketide metabolite, which selectively inhibits IL-6 induced SEAP expression by blocking the binding of activated Stat3 dimers to DNA. In addition, Galiellalactone can inhibit Stat3 without affecting tyrosine and serine phosphorylation of the Stat3 transcription factor. Furthermore, studies indicate that Galiellalactone may be an ideal tool in dissecting the JAK/STAT pathways due to its selective inhibition of Stat3.
Galiellalactone (CAS 133613-71-5) References
- Frederick Douglass, Portrait of a black militant. A study in the family romance. | Weissman, SM. 1975. Psychoanal Study Child. 30: 725-51. PMID: 1105621
- Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities. | Köpcke, B., et al. 2002. J Antibiot (Tokyo). 55: 36-40. PMID: 11918063
- Synthesis of (-)-galiellalactone. | Johansson, M. and Sterner, O. 2002. J Antibiot (Tokyo). 55: 663-5. PMID: 12243458
- Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3. | Hellsten, R., et al. 2008. Prostate. 68: 269-80. PMID: 18163422
- Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells. | Hellsten, R., et al. 2011. PLoS One. 6: e22118. PMID: 21779382
- Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. | Don-Doncow, N., et al. 2014. J Biol Chem. 289: 15969-78. PMID: 24755219
- Galiellalactone analogs and their possible precursors from Sarcosomataceae. | Tian, JF., et al. 2015. Fitoterapia. 101: 92-8. PMID: 25592721
- Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. | García, V., et al. 2016. Oncotarget. 7: 4490-506. PMID: 26683224
- Galiellalactone inhibits the STAT3/AR signaling axis and suppresses Enzalutamide-resistant Prostate Cancer. | Thaper, D., et al. 2018. Sci Rep. 8: 17307. PMID: 30470788
- Novel Galiellalactone Analogues Can Target STAT3 Phosphorylation and Cause Apoptosis in Triple-Negative Breast Cancer. | Ko, H., et al. 2019. Biomolecules. 9: PMID: 31058868
- The STAT3 inhibitor galiellalactone inhibits the generation of MDSC-like monocytes by prostate cancer cells and decreases immunosuppressive and tumorigenic factors. | Hellsten, R., et al. 2019. Prostate. 79: 1611-1621. PMID: 31348843
- Stereoretentive Nucleophilic Substitution at the Tetrasubstituted Carbon of Galiellalactone. | Escobar, Z., et al. 2020. J Org Chem. 85: 7704-7710. PMID: 32420737
- STAT3 inhibition with galiellalactone effectively targets the prostate cancer stem-like cell population. | Canesin, G., et al. 2020. Sci Rep. 10: 13958. PMID: 32811873
Inhibitor of:
IL-6, LIF, Spi-B, and Stat3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Galiellalactone, 1 mg | sc-202165 | 1 mg | $410.00 |