Molecular structure of DMNB, CAS Number: 20357-25-9
DMNB (CAS 20357-25-9)
See product citations (2)
Alternate Names:
6-Nitroveratraldehyde
Application:
DMNB is a vanillin derivative and potent inhibitor of DNA-PK
CAS Number:
20357-25-9
Purity:
≥90%
Molecular Weight:
211.2
Molecular Formula:
C9H9NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a cell-permeable vanillin derivative and potent inhibitor of DNA-dependent protein kinase. Shown in experiments to increase DR4/DR5 mRNA levels and their surface expression and decrease c-FLIP mRNA levels in K562 cells. The inhibition of DMNB on the DNA-PK/Akt pathway and caspase activation in K562 cells increased the potentcy of apoptosis. This product was also reported to sensitize cells to Cisplatin.
DMNB (CAS 20357-25-9) References
- Vanillins--a novel family of DNA-PK inhibitors. | Durant, S. and Karran, P. 2003. Nucleic Acids Res. 31: 5501-12. PMID: 14500812
- Sensitization of human K562 leukemic cells to TRAIL-induced apoptosis by inhibiting the DNA-PKcs/Akt-mediated cell survival pathway. | Kim, MJ., et al. 2009. Biochem Pharmacol. 78: 573-82. PMID: 19464267
- High susceptibility of metastatic cells derived from human prostate and colon cancer cells to TRAIL and sensitization of TRAIL-insensitive primary cells to TRAIL by 4,5-dimethoxy-2-nitrobenzaldehyde. | Kim, HB., et al. 2011. Mol Cancer. 10: 46. PMID: 21513580
- Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm. | Richardson, SL. and Swietach, P. 2016. Sci Rep. 6: 36018. PMID: 27777410
- Native Chemical Ligation Directed by Photocleavable Peptide Nucleic Acid (PNA) Templates. | Middel, S., et al. 2017. Chembiochem. 18: 2328-2332. PMID: 28987009
- Photocontrolled Release of Doxorubicin Conjugated through a Thioacetal Photocage in Folate-Targeted Nanodelivery Systems. | Wong, PT., et al. 2017. Bioconjug Chem. 28: 3016-3028. PMID: 29148732
Inhibitor of:
DNA-PK, and translin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DMNB, 5 g | sc-202142 | 5 g | $50.00 |