Chlorothricin (CAS 34707-92-1)

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Application:	A spirotetronic acid antibiotic inhibitor of pyruvate carboxylase
CAS Number:	34707-92-1
Purity:	>99%
Molecular Weight:	955.5
Molecular Formula:	C₅₀H₆₃CIO₁₆

Description

Chlorothricin is a spirotetronic acid macrolide antibiotic produced by Streptomyces antibioticus. Chlorothricin demonstrates inhibition of cholesterol biosynthesis by impeding on the mevalonate pathway. Chlorothricin is described to inhibit pyruvate carboxylases isolated from both Bacillus stearothermophilus and chicken livers, and to inhibit acetyl coenzyme A (CoASAc)-independent oxalacetate synthesis by pyruvate carboxylase of rat liver.

Technical Information

Appearance:	White powder
Physical State:	Solid
Derived from:	Streptomyces sp. MST-AS5342
Solubility:	Solubility: ethyl acetate, ethanol, methanol, DMF or DMSO.
Storage:	Store at -20° C

Safety and Reference Information

PubChem CID:	6438432
SMILES:	C[C@@H]1C[C@@]23[C@H](/C=C/CCCC[C@@H]4C=C[C@H]5[C@H]([C@@]4(C(=O)OC(=C(O2)O) C3=O)C)CCC[C@@H]5OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC(=O)C8=C(C=CC(=C8C)Cl)OC) O)C=C1C(=O)O

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Schindler, P.W. and Zähner, H. 1973. Eur. J. Biochem. 39: 591-600. PMID: 4775066
2. Schindler, P.W. and Scrutton, M.C. 1975. Eur. J. Biochem. 55: 543-553. PMID: 1175611
3. Mascaretti, O.A., et al. 1981. Biochemistry. 20: 919-924. PMID: 7011379
4. Kawashima, A., et al. 1992. J. Antibiot. 45: 207-212. PMID: 1556012
5. Jia, X.Y., et al. 2006. Chem. Biol. 13: 575-585. PMID: 16793515
6. Nakajima, H., et al. 2007. Biochem. Biophys. Res. Commun. 356: 260-265. PMID: 17350598
7. Sun, Y., et al. 2008. Chembiochem. 9: 150-156. PMID: 18046685

SDS

Datasheet/SDS