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Bakuchiol (CAS 10309-37-2)

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Alternate Names:
4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
Application:
Bakuchiol is a PTP1B and DNA polymerase inhibitor
CAS Number:
10309-37-2
Purity:
≥97%
Molecular Weight:
256.4
Molecular Formula:
C18H24O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Bakuchiol, a meroterpene phenol, is naturally derived from the seeds and leaves of the plant Psoralea corylifolia and other botanical sources. It has garnered significant interest in scientific research due to its role as a functional analog of retinol, providing a basis for comparative studies on cellular signaling pathways without the typical irritations associated with retinoids. Bakuchiol′s mechanism of action involves modulating gene expression similarly to retinol, thereby regulating proteins critical for cell differentiation and proliferation. Its capacity to influence these pathways makes it particularly useful in studies aimed at understanding cellular aging processes and gene regulation mechanisms, especially in dermatological research. Furthermore, Bakuchiol has been utilized to explore its antioxidant properties, examining how it scavenges free radicals and protects cells from oxidative stress. This is pivotal for investigations into the molecular foundations of cellular defense mechanisms against environmental stressors. Bakuchiol′s application extends to studies on its anti-inflammatory properties, providing insights into its interactions with pathways involving nuclear factor-kappa B (NF-κB), a protein complex that plays a crucial role in managing cellular responses to inflammation. Through these research applications, Bakuchiol contributes to a broader understanding of molecular biology and biochemistry.


Bakuchiol (CAS 10309-37-2) References

  1. Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages.  |  Pae, HO., et al. 2001. Int Immunopharmacol. 1: 1849-55. PMID: 11562076
  2. Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities.  |  Backhouse, CN., et al. 2001. J Ethnopharmacol. 78: 27-31. PMID: 11585684
  3. Antioxidative components of Psoralea corylifolia (Leguminosae).  |  Haraguchi, H., et al. 2002. Phytother Res. 16: 539-44. PMID: 12237811
  4. Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain.  |  Adhikari, S., et al. 2003. Chem Res Toxicol. 16: 1062-9. PMID: 12971793
  5. Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent.  |  Bapat, K., et al. 2005. Appl Radiat Isot. 62: 389-93. PMID: 15607914
  6. In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia.  |  Kim, YC., et al. 2005. Planta Med. 71: 87-9. PMID: 15678382
  7. Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo.  |  Park, EJ., et al. 2005. Planta Med. 71: 508-13. PMID: 15971120
  8. Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.  |  Park, EJ., et al. 2007. Eur J Pharmacol. 559: 115-23. PMID: 17292878
  9. Bakuchiol Contributes to the Hepatotoxicity of Psoralea corylifolia in Rats.  |  Li, ZJ., et al. 2017. Phytother Res. 31: 1265-1272. PMID: 28639266
  10. Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - Cullen corylifolium (L.) Medik.  |  Jafernik, K., et al. 2021. Nat Prod Res. 35: 5828-5842. PMID: 33185126
  11. Bakuchiol - a natural meroterpenoid: structure, isolation, synthesis and functionalization approaches.  |  Adarsh Krishna, TP., et al. 2022. RSC Adv. 12: 8815-8832. PMID: 35424800
  12. Recent Advances in the Chemistry and Biology of Bakuchiol and its Derivatives: An Updated Review.  |  Gupta, N., et al. 2023. Anticancer Agents Med Chem. 23: 747-764. PMID: 35959907
  13. Bakuchiol: A Potential Anticancer Compound from Psoralea corylifolia Linn.  |  Chopra, B., et al. 2023. Anticancer Agents Med Chem.. PMID: 36717993

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Bakuchiol, 1 mg

sc-202075
1 mg
$45.00

Hello, I am a natural skin care formulator and I am interested in adding Bakuchiol to a prod. What percentage of Bakuchios recommended to be effective in an oil based product? Any info on how to use this ingredient in natural skin care is appreciated.

Asked by: alysha
Products are provided for research or laboratory use only (RUO) and are not to be administered to humans or used for medical diagnostics.
Answered by: Technical Support Europe
Date published: 2017-12-27
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Rated 5 out of 5 by from Park et alPark et al. (PubMed ID 17292878) found that bakuchiol reduced activated hepatic stellate cells of rats recovering from liver injury by inducing apoptosis via activation of caspase 3. -SCBT Publication Review
Date published: 2015-02-23
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Bakuchiol is rated 5.0 out of 5 by 1.
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