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Bakuchiol (CAS 10309-37-2)

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Synonym:4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
Application:A PTP1B and DNA polymerase inhibitor
CAS Number:10309-37-2
Purity:≥97%
Molecular Weight:256.4
Molecular Formula:C18H24O
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Bakuchiol sc-202075 1 mg $40
Description
Bakuchiol is an antioxidant inhibitor of protein tyrosine phosphatase 1B (PTP1B). It also acts as an inhibitor of mitochondrial lipid peroxidation and inducible nitric oxide synthase (iNOS; NOS II) expression. Bakuchiol is also a DNA polymerase inhibitor which shows antimicrobial and cytotoxic activity.
Technical Information
Appearance:Oil
Physical State:Liquid
Derived from:Psoralea corylifolia
Solubility:Soluble in DMSO, and 100% ethanol.
Storage:Store at -20° C
Melting Point:106.00 °C (Predicted)
Boiling Point:391.38 °C (Predicted)
Density:0.96 g/mL (Predicted)
Refractive Index:n20D 1.56 (Predicted)
IC50:HeLa: IC50 = 11 µM (human); AGS: IC50 = 15.3 µM (human); T47D: IC50 = 28.9 µM (human)
pK Values:pKa: 10.1 (Predicted)
Safety and Reference Information
PubChem CID:5468522
MDL Number:MFCD01707441
SMILES:CC(=CCCC(C)(C=C)C=CC1=CC=C(C=C1)O)C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Pae, H.O. et al. 2001. Int. Immunopharmacol. 1(9-10): 1849-1855. PMID: 11562076
2. Backhouse, C.N. et al. 2001. J Ethnopharmacol. 78(1): 27-31. PMID: 11585684
3. Haraguchi, H. et al. 2002. Phytother Res. 16(6): 539-544. PMID: 12237811
4. Adhikari, S. et al. 2003. Chem. Res. Toxicol. 16(9): 1062-1069. PMID: 12971793
5. Bapat, K. et al. 2005. Appl Radiat Isot. 62(3): 389-393. PMID: 15607914
6. Kim, Y.C. et al. 2005. Planta Med. 71(1): 87-89. PMID: 15678382
7. Park, E.J. et al. 2005. Planta Med. 71(6): 508-513. PMID: 15971120
8. Park, E.J. et al. 2007. Eur. J. Pharmacol. 559(2-3): 115-123. PMID: 17292878
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