AEBSF, Hydrochloride (CAS 30827-99-7)

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Application:	A TGF beta inhibitor, JNK activator, and p38 Map activator
CAS Number:	30827-99-7
Purity:	>97%
Molecular Weight:	239.69
Molecular Formula:	C₈H₁₀FNO₂S HCl

Ordering Information

Product Name	Catalog #	Unit	Price
AEBSF, Hydrochloride	sc-202041	50 mg	$46
AEBSF, Hydrochloride	sc-202041A	100 mg	$158
AEBSF, Hydrochloride	sc-202041B	5 g	$390

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

Description

AEBSF is a broad spectrum, water soluble, irreversible serine protease inhibitor. It has been shown to inhibit the constitutive production of beta amyloid (A beta) in five different human cell lines, both neural and non-neural. AEBSF also inhibits activation of TGFβ (transforming growth factor beta), moderately inhibits CD26 (Dipeptidyl peptidase IV: DPP IV) and activates JNK and p38 MAP kinases. AEBSF is a b-secretase inhibitor that has been shown to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations. This product maintains stability at slightly acidic aqueous solutions and serves as a nontoxic alternative to PMSF (sc-3597) and DFP.

Usage

• Use AEBSF at the same molar concentrations (0.1 - 1.0 mM) as PMSF for most applications.

Technical Information

Appearance:	White to off-white
Physical State:	Solid
Solubility:	Soluble in water (10 g/L) at 20 °C, and DMSO (50 mg/ml).
Storage:	Store at room temperature
Melting Point:	183 °C
Boiling Point:	292.5 °C at 760 mmHg (Predicted)

Safety and Reference Information

Transport:	UN 3261, Class 8, Packing group II
WGK Germany:	3
PubChem CID:	186136
MDL Number:	MFCD00132962
Beilstein Registry:	7604627
SMILES:	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Baker, B.R., et al. 1971. J. Med. Chem. 14: 119-125. PMID: 5544395
2. Markwardt, F., et al. 1974. Biochem. Pharmacol. 23: 2247-2256. PMID: 4859519
3. Lawson, W.B., et al. 1982. Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 109: 52-60. PMID: 6177608
4. Ohkubo, I., et al. 1994. J. Biochem. 116: 1182-1186. PMID: 7896751
5. Citron, M., et al. 1996. Neuron. 17: 171-179. PMID: 8755488
6. Solovyan, V.T. and Keski-Oja, J. 2006. J. Cell. Physiol. 207: 445-453. PMID: 16447253
7. Seto, T., et al. 2009. Biochem. Biophys. Res. Commun. 379: 681-685. PMID: 19103172

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SDS

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