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8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate sodium salt: sc-202028 |
| Datasheet | MSDS |
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- Specifications
- Offered as 1 mg (sc-202028) and 5 mg (sc-202028A) sizes
- CAS Number: 510774-50-2
- Molecular Weight: 507.8
- Molecular Formula: C17H16CIN5O6PS ·Na
- Purity: 98%
- Physical Appearance: white to off-white powder
- Solubility: Soluble in water, aqueous buffers, DMSO, dimethyl formamide or methanol.
- SMILES: CO[C@@H]1[C@@H]2OP(=O)(O[Na])OC[C@H]2O[C@H]1n1c(Sc
2ccc(Cl)cc2)nc2c(N)ncnc12
- Description
- Specific, potent and membrane permeant activator of the Epac cAMP receptor. Activates Epac1 and Epac2, the guanine nucleotide-exchange factors (GEFs) for the small GTPases Rap1 and Rap2. Does not activate protein kinase A (PKA), neither in vitro nor in vivo and is therefore a valuable tool to specifically discriminate between PKA- and Epac-mediated effects. Since a free 2'-ribose hydroxyl group in cyclic AMP is essential for stimulation of PKA, the methylated structure of 8-CPT-2'-O-Me-cAMP is an extremely poor PKA activator. Its high lipophilicity allows for good membrane permeability in most biosystems and its increased resistance towards phosphodiesterases prevents rapid hydrolysis.
- Storage
- For Research Use Only
- References
- 1. Enserink, J.M., et al. 2002. Nat. Cell Biol. 4: 901-906. PMID: 12402047
2. Kang, G., et al. 2003. J. Biol. Chem. 278: 8279-8285. PMID: 12496249
3. Rangarajan, S., et al. 2003. J. Cell Biol. 160: 487-493. PMID: 12578910
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8-(4-Chlorophenylthio)-2'-O-methyladenosine 3',5'-cyclic Monophosphate sodium salt
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