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- Specifications
- Offered as 5 mg (sc-201551) and 25 mg (sc-201551A) sizes
- CAS Number: 579-13-5
- Molecular Weight: 791.07
- Molecular Formula: C45H74O11
- Purity: >95%
- Derived from: Streptomyces sp.
- Form: Solid
- Physical Appearance: White solid
- Solubility: Soluble in DMSO (300mg/ml), ethanol (200mg/ml) and acetone (800mg/ml)
- SMILES: CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC
(C(C(C(=O)C(C(C(C(=O)C
(C(C(CC=CC=C1)C)O)(C)O)C)O)
C)C)O)C)C
- Description
- Oligomycin A inhibits mitochondrial ATPases (F1F0) bound to the cell membrane. This compound stimulates lysosome acidification due to shunting of membrane potential at a concentration of 1.5-3 μM. The compound has been observed to Induce apoptosis in a variety of cell types along with inducing a switch from the apoptotic to necrotic pathway. It also exhibits broad nematocidal, antifungal, and antitumor activities. Oligomycin A has caused dissipated mitochondrial membrane potential, decreased cytoplasmic ATP contents and disassembled metaphase II oocyte spindles when introduced to mouse oocytes.
- Storage
- Safety
- UN Number: UN 2811, Class 6.1, Packing group III
- Risk Statements: R22
- For Research Use Only
- Reference Numbers
- References
- 1. Linnett, P.E., et al. 1979. Meth. Enzymol. 55: 472-518. PMID: 156854
2. Van Dyke, R.W. 1993. Am. J. Physiol. 265: C901-C917. PMID: 8238315
3. Fitch, M.E., et al. 2000. Cell Death Differ. 7: 338-349. PMID: 10773818
4. Peachman, K.K., et al. 2001. Proc. Natl. Acad. Sci. U.S.A. 98: 1717-1722. PMID: 11172017
5. Zhang, X., et al. 2006. Cell Res. 16: 841-850. PMID: 16983401
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Oligomycin A
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