ECAM Background Information The epithelial cell adhesion molecule Ep-CAM, which is also designated tumor-associated calcium signal transducer 1 and MK-1, is a monomeric membrane glycoprotein that is expressed in most normal human epithelium and carcinomas. The human Ep-CAM gene encodes a 314 amino acid protein that is expressed as two forms, a major form and a minor form, which are reduced upon treatment with the amino-glycosylation inhibitor tunicamycin. Ep-CAM is overexpressed in a variety of carcinomas and is, therefore, a potential target for the visualization and therapy of human solid tumors. Ep-CAM contains an extracellular domain containing two epidermal growth factor-like repeats, followed by a cysteine poor region, which is necessary for the adhesion properties of the molecule.
Ep-CAM (H-70) Product Citations
See how others have used Ep-CAM (H-70): sc-20154 antibody and or Ep-CAM (H-70) antibody conjugates.
1 total citations
Loading citations.
Ep-CAM (H-70)
Click on image to enlarge
Ep-CAM (H-70): sc-20154. Western blot analysis of Ep-CAM expression in non-transfected 293T: sc-117752 (A), human Ep-CAM transfected 293T: sc-113013 (B) and A-431 (C) whole cell lysates.
Ep-CAM (H-70): sc-20154. Western blot analysis of Ep-CAM expression in non-transfected: sc-117752 (A) and human Ep-CAM transfected: sc-159303 (B) 293T whole cell lysates.
