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Iso-olomoucine (CAS 101622-50-8)

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Synonym:6-Benzylamino-2-(2-hydroxyethylamino)-7-methylpurine
Application:A potent and selective inhibitor of cdc2, cdk and orther cyclin related kinases
CAS Number:101622-50-8
Molecular Weight:298.35
Molecular Formula:C15H18N6O
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Iso-olomoucine sc-201528 5 mg $81
Iso-olomoucine sc-201528A 25 mg $353
Description
Iso-olomoucine is a negative control compound for Olomoucine (sc-3509), a potent and selective inhibitor of Cdc2, Cdk and orther cyclinrelated kinases.
Technical Information
Physical State:Solid
Solubility:Soluble in ethanol (~0.3 mg/ml), DMSO (~15 mg/ml), DMF, a 1:10 solution of DMSO:PBS(pH 7.2) (~0.1 mg/ml), and methanol.
Storage:Store at -20° C
Boiling Point:579.56 °C at 760 mmHg
Density:1.36 g/cm3
Refractive Index:n20D 1.69
IC50:CDK5: IC50 = >1 mM; olomoucine: IC50 = ~37 µM; p34cdk1/cyclin B: IC50 = >500 µM; p33cdk5/p35: IC50 = >1 mM; p34cdk4/cyclin D: IC50 = >1 mM
Safety and Reference Information
PubChem CID:512292
MDL Number:MFCD00189361
SMILES:CN1C=NC2=C1C(=NC(=N2)NCCO)NCC3=CC=CC=C3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Veselý, J., et al. 1994. Eur. J. Biochem. 224: 771-786. PMID: 7925396
2. Krucher, N.A., et al. 1997. Cell. Mol. Neurobiol. 17: 495-507. PMID: 9353591
3. Alessi, F., et al. 1998. Exp. Cell Res. 245: 8-18. PMID: 9828096
4. Taylor, J.R., et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 4147-4152. PMID: 17360491
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