Molecular structure of Gabapentin, CAS Number: 60142-96-3
Gabapentin (CAS 60142-96-3)
See product citations (7)
Alternate Names:
Gabapentin is also known as 1-(aminomethyl)-cyclohexaneacetic acid.
Application:
Gabapentin is a compound structurally similar to GABA that binds to voltage-sensitive Ca2+ channels
CAS Number:
60142-96-3
Purity:
≥98%
Molecular Weight:
171.20
Molecular Formula:
C9H17NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Gabapentin, a structural analog of the neurotransmitter gamma-aminobutyric acid (GABA), is a compound of interest in research due to its unique mechanism of action. Unlike other GABA analogs, gabapentin does not act directly on GABA receptors. Instead, it binds with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels. In research applications, gabapentin′s ability to modulate neuronal activity without the typical GABAergic effects provides a unique tool for scientists investigating the in vivo pathophysiology of neural excitability and synaptic transmission. Its action on calcium channels. The compound is valuable for experimental models aiming to understand the underlying mechanisms of various neurological mechanisms, especially those involving abnormal excitatory signaling.
Gabapentin (CAS 60142-96-3) References
- Allosteric modulation of [(3)H]gabapentin binding by ruthenium red. | Taylor, MT. and Bonhaus, DW. 2000. Neuropharmacology. 39: 1267-73. PMID: 10760368
- Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. | Shimoyama, M., et al. 2000. Pain. 85: 405-414. PMID: 10781913
- A microdialysis study on the mechanism of action of gabapentin. | Timmerman, W., et al. 2000. Eur J Pharmacol. 398: 53-7. PMID: 10856447
- Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. | Fink, K., et al. 2000. Br J Pharmacol. 130: 900-6. PMID: 10864898
- Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. | Caraceni, A., et al. 2004. J Clin Oncol. 22: 2909-17. PMID: 15254060
- Mechanism of action of alpha2delta ligands: voltage sensitive calcium channel (VSCC) modulators. | Stahl, SM. 2004. J Clin Psychiatry. 65: 1033-4. PMID: 15323585
- Randomised controlled trial of gabapentin in Complex Regional Pain Syndrome type 1 [ISRCTN84121379]. | van de Vusse, AC., et al. 2004. BMC Neurol. 4: 13. PMID: 15453912
- A placebo-controlled trial of gabapentin for painful HIV-associated sensory neuropathies. | Hahn, K., et al. 2004. J Neurol. 251: 1260-6. PMID: 15503108
- Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein. | Schwarz, JB., et al. 2005. J Med Chem. 48: 3026-35. PMID: 15828841
- Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy. | Goa, KL. and Sorkin, EM. 1993. Drugs. 46: 409-427. PMID: 7693432
- Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. | Upton, N. 1994. Trends Pharmacol Sci. 15: 456-63. PMID: 7886818
- The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel. | Gee, NS., et al. 1996. J Biol Chem. 271: 5768-76. PMID: 8621444
- GABA and its receptors in the spinal cord. | Malcangio, M. and Bowery, NG. 1996. Trends Pharmacol Sci. 17: 457-62. PMID: 9014500
- Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. | Field, MJ., et al. 1997. Br J Pharmacol. 121: 1513-22. PMID: 9283683
- A summary of mechanistic hypotheses of gabapentin pharmacology. | Taylor, CP., et al. 1998. Epilepsy Res. 29: 233-49. PMID: 9551785
- Gabapentin potentiates the antiseizure activity of certain anticonvulsants in DBA/2 mice. | De Sarro, G., et al. 1998. Eur J Pharmacol. 349: 179-85. PMID: 9671096
Inhibitor of:
AARD, ALAS-H, AZ2, BCKDE1A, BCKDHB, C230078M14Rik, CaBP4, Cacna2d1, Cacna2d3, Calcium Channel Protein, CAT-3, ERICH1, FAM194B, GADL1, GLUD1, GLUD2, GluR-δ1, GPx-8, HCN1, HCN4, IGSF9, L-type Ca++ α1S, L-type Ca++ CP γ7, L-type Ca++ CP γ8, LGI2, LRFN5, mGluR-6, MrgB4, MRGF, Myozenin (MYOZ), N-type Ca CP α1B, N-type calcium channel α1B, NCKX3, Neu, Neuritin, Olfr427, Olfr822, Olfr823, Olfr855, Olfr857, Olfr859, Olr192, Olr211, Olr255, Olr806, ORNT1, P/Q-type Ca++ CP α1A, parvalbumin α, PCP-2, PNKD, Raftlin, Rit2, ROG, RTP4, SAPAP2, SEZ6L2, SHISA4, SLC7A12, SLITRK5, SNAT1, Spatacsin, SV2C, Synaptotagmin III, Synaptotagmin IV, Synaptotagmin VII, Unc18-1, Unc79, and Y+LAT1.Activator of:
ABAT, Acnat1, BAT2, BBOX1, BC014805, CRMP-4, DREAM, Flipt1, GABAB R1, GluR-δ2, GlyR α4, Grid2ip, HEM1, KCNH8, KCNT2, KCTD3, KCTD4, L-type Ca++ CP α1C/1D/1F/1S, L-type Ca++ CP β1, L-type Ca++ CP β3, Leu-enkephalin, LGI1, MrgA3, Mrgprh, parvalbumin β, PICK1, PNMAL1, PRODH2, Rim4, SLC7A6, SLITRK1, SLITRK3, SRPX2, SV2A, T-type Ca++ CP α1G, T-type Ca++ CP α1I, T-type calcium channel α1G, T-type calcium channel α1I, TMEM14C, and VILIP-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gabapentin, 20 mg | sc-201481 | 20 mg | $52.00 | |||
Gabapentin, 100 mg | sc-201481A | 100 mg | $92.00 | |||
Gabapentin, 1 g | sc-201481B | 1 g | $132.00 |