DL-PDMP (CAS 73257-80-4)
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DL-PDMP is a synthetic analog of sphingosine and is used in research for its ability to inhibit glucosylceramide synthase, an enzyme involved in the biosynthesis of glycosphingolipids. Studies often utilize DL-PDMP to understand the role of glycosphingolipids in cell membrane structure and function, particularly in the context of cellular signaling and membrane dynamics. Its inhibitory effect on glucosylceramide accumulation is also valuable in research related to lipid storage. Additionally, DL-PDMP serves as a tool in the exploration of the mechanisms of apoptosis and autophagy, as the disruption of glycosphingolipid metabolism can impact these cellular processes. The chemical′s application extends to the study of cancer cell proliferation, where it has been used to investigate the role of glycosphingolipids in tumor growth.
DL-PDMP (CAS 73257-80-4) References
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- Effects of a sphingolipid synthesis inhibitor on membrane transport through the secretory pathway. | Rosenwald, AG., et al. 1992. Biochemistry. 31: 3581-90. PMID: 1567816
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- Effect of an inhibitor of glucosylceramide synthesis on cultured rabbit skin fibroblasts. | Uemura, K., et al. 1990. J Biochem. 108: 525-30. PMID: 2149853
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- Preparation of the active isomer of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase. | Inokuchi, J. and Radin, NS. 1987. J Lipid Res. 28: 565-71. PMID: 2955067
- Antitumor activity via inhibition of glycosphingolipid biosynthesis. | Inokuchi, J., et al. 1987. Cancer Lett. 38: 23-30. PMID: 3690511
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- Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases. | Rani, CS., et al. 1995. J Biol Chem. 270: 2859-67. PMID: 7852361
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DL-PDMP, 10 mg | sc-201391 | 10 mg | $117.00 | |||
DL-PDMP, 25 mg | sc-201391B | 25 mg | $268.00 | |||
DL-PDMP, 50 mg | sc-201391A | 50 mg | $505.00 | |||
DL-PDMP, 100 mg | sc-201391C | 100 mg | $821.00 |