Molecular structure of Castanospermine, CAS Number: 79831-76-8
Castanospermine (CAS 79831-76-8)
See product citations (10)
Alternate Names:
6-Epicastanospermine
Application:
Castanospermine is a glycosidase inhibitor and antiinflammatory agent
CAS Number:
79831-76-8
Purity:
≥95%
Molecular Weight:
189.21
Molecular Formula:
C8H15NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Castanospermine is an indolizidine alkaloid found in the seeds of the Australian chestnut tree, Castanospermum australe. It is primarily investigated for its potent activity as a glucosidase inhibitor, which makes it a useful tool in glycobiology research. By inhibiting glucosidase enzymes, castanospermine affects the glycosylation process, which is essential for proper folding and function of many proteins. Its ability to disrupt this process allows researchers to study the role of protein glycosylation in various biological systems and processes, including viral infections, where glycosylation of viral envelope proteins is for infectivity. Additionally, castanospermine is utilized to examine the cellular mechanisms underlying glycoprotein processing, trafficking, and degradation. This compound also aids in the exploration of the link between altered glycosylation and conditions including certain lysosomal storage disorders.
Castanospermine (CAS 79831-76-8) References
- Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. | Whitby, K., et al. 2005. J Virol. 79: 8698-706. PMID: 15994763
- Thermospray liquid chromatographic-mass spectrometric analysis of castanospermine-related alkaloids in Castanospermum australe. | Chen, TM., et al. 1990. J Nat Prod. 53: 359-65. PMID: 2380711
- Castanospermine inhibits the function of the low-density lipoprotein receptor. | Edwards, EH., et al. 1989. Biochemistry. 28: 7679-87. PMID: 2558711
- Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation. | Hibberd, AD., et al. 2016. World J Transplant. 6: 206-14. PMID: 27011919
- Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. | Gruters, RA., et al. Nature. 330: 74-7. PMID: 2959866
- Castanospermine reduces Zika virus infection-associated seizure by inhibiting both the viral load and inflammation in mouse models. | Tharappel, AM., et al. 2020. Antiviral Res. 183: 104935. PMID: 32949636
- The iminosugars celgosivir, castanospermine and UV-4 inhibit SARS-CoV-2 replication. | Clarke, EC., et al. 2021. Glycobiology. 31: 378-384. PMID: 32985653
- Castanospermine inhibits alpha-glucosidase activities and alters glycogen distribution in animals. | Saul, R., et al. 1985. Proc Natl Acad Sci U S A. 82: 93-7. PMID: 3881759
- Castanospermine, a tetrahydroxylated alkaloid that inhibits beta-glucosidase and beta-glucocerebrosidase. | Saul, R., et al. 1983. Arch Biochem Biophys. 221: 593-7. PMID: 6404222
- Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin. | Pan, YT., et al. 1983. Biochemistry. 22: 3975-84. PMID: 6615812
- Effects of the anti-inflammatory compounds castanospermine, mannose-6-phosphate and fucoidan on allograft rejection and elicited peritoneal exudates. | Bartlett, MR., et al. 1994. Immunol Cell Biol. 72: 367-74. PMID: 7835980
- Inhibitors of pig kidney trehalase. | Kyosseva, SV., et al. 1995. Arch Biochem Biophys. 316: 821-6. PMID: 7864639
- Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2. | Ahmed, SP., et al. 1995. Biochem Biophys Res Commun. 208: 267-73. PMID: 7887939
- The effects of castanospermine and swainsonine on the activity and synthesis of intestinal sucrase. | Pan, YT., et al. 1993. Arch Biochem Biophys. 303: 134-44. PMID: 8489256
Inhibitor of:
α-Glucosidase, α4Gn-T, β-1,3-Gal-T1, β-1,3-Gal-T2, β-1,3-Gal-T3, β-1,3-Gal-T6, β-1,4-Gal-T1, β-1,4-Gal-T2, β-1,4-Gal-T3, β-1,4-Gal-T4, β-1,4-Gal-T5, β-1,4-Gal-T6, β-1,4-Gal-T7, β-1,4-GalNAc-T2, β-1,4-GalNAc-T3, β-1,4-GalNAc-T4, β-4-Gal-T4, β-Gal, β-Galactose Dehydrogenase S, β-glucosidase 2, β3Gn-T1, β3Gn-T4, β3Gn-T6, β3Gn-T7, β3Gn-T8, β3Gn-T9, 4922502D21Rik, 4933406M09Rik, 4933434I20Rik, A530082C11Rik, AGL, AI464131, ALG10, ALG10B, ALG13, ALG14, ALG1L2, ALG2, ALG3, ALG6, ALG8, ALG9, Amylase 1a, Amylase 1b, Amylase 1c, Amylase 2, Amylase 2-2, Amylase 2a2, Amylase 2a3, Amylase 2a4, Amyloglucosidase, B3GNTL1, beta-glucosidase, Blood Group A1, A2 antigen, Blood Group A1, A2, A3 antigen, Blood Group AB antigen, Blood Group B antigen, Blood Group H ab antigen, Blood Group H n, Blood Group Lewis, Blood Group Lewis a, C14orf109, C1GALT1, C85492, CLEC-18, CLN6, COG1, COG2, COG5, COG8, CSGlcA-T, D730048I06Rik, D930020B18Rik, DC2_Ostc, DPAGT1, DPM1, DPM2, EDEM3, EG619597, EG667977, Endoglycosidase, Endoglycosidase H, EOGT_A130022J15Rik, EP58, Erd2, ERGIC-53L, FIV p27, FUCA1, FUCA2, Fucokinase, FucT-V, FucT-VI, FucT-VII, FucT-X, FucT-XI, Fukutin, FUT1, FX, GALE, galectin-13, galectin-14, galectin-16, galectin-2, galectin-6, galectin-8, GALK2, GalNAc-TL2, GalNAc-TL4, GalNAcT-2, GANC, GBE1, GCNT4, Ggta1, GLB1L, GLB1L3, GlcAT-I, GLG1, Glt28d2, GLT8D1, GLT8D2, Glucosidase I, Glucosidase II alpha, Glucosidase IIβ, glycogen synthase 1, Glycogenin (GYG), Glycophorin B, GMPPA, GNPTAB, GNS, GnT-I, GnT-II, GnT-IVA, GnT-IVB, GnT-IVH, GOLGA6A, GOLGA6C, GOLGA6D, GOLGA6L4, GOLGA6L9, GOLGA7, GOLGA7B, GOLPH3, GTDC1, GXYLT2, H2-Q8, HEXB, HLA-B7, HLA-E, HSV-1 VP22, HUGT2, ISPD, ITM1, KDEL receptor 1, KDEL receptor 2, KDEL receptor 3, KDELC2, KDELR1 (HDEL), LCT, LGALS9B, LOC645202, LOC729556, LSECtin, Lunapark, LYAG, LYG2, Mac-2BP, MagT1, Maltase-glucoamylase, MAN1A1, MAN1A2, MAN1C1, MAN2A1, MAN2A2, MAN2B2, MANBA, MANEA, MANEAL, MGAT1, Mgl2, MLEC, MPDU1, Mpi, MS4A6C, Muc21, Mucin 10, Mucin 11/12, Mucin 19, Mucin 21, Mucin 22, NAGPA, NANS, O-Glycosidase, OST4, Phytohemagglutinin-L, Phytohemagglutinin-M, PIG-A, PIG-G, PIG-L, PIG-O, PIG-S, PIG-W, PIG-Z, Pigr, PMM1, PMM2, PNGase, POFUT2, Polyoma virus VP1, POMGnT1, POMT1, Rae-1β, Rer1, Ribophorin I, Ribophorin II, Ricin B, rotavirus C vp4, rotavirus C vp6, rotavirus NSP4, rotavirus vp7, SDF-2L1, SFT2D1, Sialyltransferase 10, Sialyltransferase 7A, Sialyltransferase 7B, Sialyltransferase 7F, Siglec-10, Siglec-15, SLC35A2, SLC35A3, SLC35A4, SLC35A5, SLC35B2, SLC35B4, SLC35C1, SLC35C2, SLC35D1, SLC35D3, SLC35E1, SLC35E3, SPINDLY, SPP, SR-α, SSEA-1, St. Louis encephalitis, St3Gal-II, St3Gal-IV, ST6GAL2, ST8Sia III, Sucrase-Isomaltase, sulfamidase, TAG-72, TAP1, Thomsen-Friedenreich, TMED4, TMTC1, TRAM, Trehalase, TRS85, UAP1, UAP1L1, UGP2, VIP36, XylT-II, ZG16, and ZG16B.Activator of:
α-Glucosidase, β-1,3-Gal-T2, β-glucosidase, β3Gn-T5, ALG1, ALG10B, ALG11, ALG1L, ALG1L2, ALG5, ALG8, Amyloglucosidase, B3GNTL1, C3orf21, C3orf39, CD164, COG7, D730048I06Rik, DPY19L1, Endoglycosidase H, ENGase, ERGIC-53L, FucT-III, FucT-IV, FucT-XI, galectin-12, GalNAc-T17, GLT8D4, GnT-IVB, GnT-VB, GPAA1, GPT, GXYLT2, KTELC1, MAN1B1, MANBAL, MPDU1, OST48, Shigatoxin 1, SLC35F2, SLC35F4, and XylT-I.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Castanospermine, 100 mg | sc-201358 | 100 mg | $180.00 | |||
Castanospermine, 500 mg | sc-201358A | 500 mg | $620.00 |