Molecular structure of Conduritol B Epoxide (CBE), CAS Number: 6090-95-5
Conduritol B Epoxide (CBE) (CAS 6090-95-5)
See product citations (12)
Alternate Names:
Conduritol B Epoxide (CBE) is known as a β-glucosidase inhibitor.
Application:
Conduritol B Epoxide (CBE) is a specific covalent β-glycosidase enzyme inhibitor that results in the accumulation of glucocerebroside.
CAS Number:
6090-95-5
Purity:
≥96%
Molecular Weight:
162.14
Molecular Formula:
C6H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Conduritol B Epoxide (CBE) is a specific covalent inhibitor of β-glucosidase which results in the accumulation of glucocerebroside. Treatment of murine peritoneal macrophages with Conduritol B Epoxide (CBE) does not seem to affect lysozyme enzyme release to the medium, cell viability, or levels of intracellular lysosomal enzymes, other than β-glucosidase activity. In vitro exposure of cells to Conduritol B Epoxide (CBE) has been reported to lead to up-regulation of CD1d (cluster of differentiation 1d) expression by THP-1 cells, which is related to an increase in mRNA expression.
Conduritol B Epoxide (CBE) (CAS 6090-95-5) References
- Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells. | Bieberich, E., et al. 1999. J Neurochem. 72: 1040-9. PMID: 10037475
- Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness. | Balreira, A., et al. 2010. Immunobiology. 215: 505-13. PMID: 19651460
- β-Glucosidase 2 (GBA2) activity and imino sugar pharmacology. | Ridley, CM., et al. 2013. J Biol Chem. 288: 26052-26066. PMID: 23880767
- Intracellular activity of lysosomal glucosylceramidase measured with 4-nonylumbelliferyl beta-glucoside. | Bieberich, E. and Legler, G. 1989. Biol Chem Hoppe Seyler. 370: 809-17. PMID: 2590464
- Glucocerebrosidase deficiency and mitochondrial impairment in experimental Parkinson disease. | Noelker, C., et al. 2015. J Neurol Sci. 356: 129-36. PMID: 26104567
- Klotho-Related Protein KLrP: Structure and Functions. | Hayashi, Y. and Ito, M. 2016. Vitam Horm. 101: 1-16. PMID: 27125736
- Delineating pathological pathways in a chemically induced mouse model of Gaucher disease. | Vardi, A., et al. 2016. J Pathol. 239: 496-509. PMID: 27234572
- In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. | Kuo, CL., et al. 2019. FEBS J. 286: 584-600. PMID: 30600575
- Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. | Artola, M., et al. 2019. J Am Chem Soc. 141: 4214-4218. PMID: 30811188
- beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell. | Newburg, DS., et al. 1986. Biochim Biophys Acta. 877: 121-6. PMID: 3087427
- Human acid beta-glucosidase. Use of conduritol B epoxide derivatives to investigate the catalytically active normal and Gaucher disease enzymes. | Grabowski, GA., et al. 1986. J Biol Chem. 261: 8263-9. PMID: 3087971
- Active site directed inhibition of a cytosolic beta-glucosidase from calf liver by bromoconduritol B epoxide and bromoconduritol F. | Legler, G. and Bieberich, E. 1988. Arch Biochem Biophys. 260: 437-42. PMID: 3124752
- Normalization of liver glucosylceramide levels in the 'Gaucher' mouse by phosphatidylserine injection. | Datta, SC. and Radin, NS. 1988. Biochem Biophys Res Commun. 152: 155-60. PMID: 3358758
- Destruction and resynthesis of mouse beta-glucosidases. | Hara, A. and Radin, NS. 1979. Biochim Biophys Acta. 582: 412-22. PMID: 33720
- Zearalenone-14-Glucoside Is Hydrolyzed to Zearalenone by β-Glucosidase in Extracellular Matrix to Exert Intracellular Toxicity in KGN Cells. | Ruan, H., et al. 2022. Toxins (Basel). 14: PMID: 35878196
Inhibitor of:
β-Galactose Dehydrogenase S, β-glucosidase 2, beta-glucosidase, GLB1L3, GM3 Synthase, HEXB, LYAG, NAGA, Sucrase-Isomaltase, and UGCG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Conduritol B Epoxide (CBE), 5 mg | sc-201356 | 5 mg | $79.00 | |||
Conduritol B Epoxide (CBE), 25 mg | sc-201356A | 25 mg | $320.00 | |||
Conduritol B Epoxide (CBE), 50 mg | sc-201356B | 50 mg | $500.00 | |||
Conduritol B Epoxide (CBE), 100 mg | sc-201356C | 100 mg | $614.00 | |||
Conduritol B Epoxide (CBE), 250 mg | sc-201356D | 250 mg | $1311.00 | |||
Conduritol B Epoxide (CBE), 1 g | sc-201356E | 1 g | $5212.00 | |||
Conduritol B Epoxide (CBE), 5 g | sc-201356F | 5 g | $20818.00 |