epitope corresponding to amino acids 96-270 mapping near the N-terminus of HERG of human origin
recommended for detection of HERG of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
HERG Background Information Human ether-a-go-go related gene (HERG) encodes the pore-forming å subunit of the delayed rectifier potassium channel IKr. The HERG subunit contains six transmembrane å-helices with a reentrant “pore-loop” between the fifth and the sixth transmembrane helices. The two N-terminal splice variants of HERG include the full-length isoform 1å and the shorter isoform 1∫. Isoform 1∫ lacks the PAS motif and deactivates at a faster rate than isoform 1å. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome.
HERG (H-175) Product Citations
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HERG (H-175)
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HERG (H-175): sc-20130. Western blot analysis of HERG expression in EOC 20 (A) and EOC 13.31 (B) whole cell lysates.
HERG (H-175): sc-20130. Western blot analysis of HERG expression in EOC 20 whole cell lysate.
