Date published: 2025-9-7

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PGE2 (CAS 363-24-6)

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Alternate Names:
PGE2 also known as Prostaglandin E2; Dinoprostone; (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid; PGE2; Dinoprostone; Cervidil; 8-isoprostaglandin E2 [MeSH: 8-isoprostaglandin E2]; 7-[(1R,2R, 3R)-3-hydroxy-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid; PGE2 [MeSH: Dinoprostone] CBiol_001945; KBioGR_000210; KBioSS_000210; Dinoprostone Prostaglandin E2; KBio2_000210; KBio2_002778
Application:
PGE2 is an extremely important eicosanoid involved in neuronal, metabolic, and immune system function
CAS Number:
363-24-6
Purity:
≥98%
Molecular Weight:
352.47
Molecular Formula:
C20H32O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Prostaglandin E2 (PGE2) is the most physiologically abundant eicosanoid, which is produced predominantly from arachidonic acid (sc-200770) by COX and PGES, and exists at some level in nearly all cell types. PGE2 acts on four different receptors termed EP1 through EP4 yielding an astounding array of biological effects. Reported effects of PGE2 include: potent vasodilation, smooth muscle relaxation, both anti- and pro-inflammatory activities, stimulates bone resorption, synergizes with LTB4, facilitates replication of AIDS virus, regulates sleep/wake cycle, demonstrates thermoregulatory action in the CNS, induces LHRH release from rat median eminence, demonstrates a protective effect on gastric mucosa, and regulates renal hemodynamics and sodium excretion.


PGE2 (CAS 363-24-6) References

  1. Paradoxical regulation by PGE-2 on release of neutrophil chemoattractants by rat bone marrow macrophages.  |  Christman, JW., et al. 1991. Prostaglandins. 41: 251-62. PMID: 1852897
  2. Prostaglandin E2 and leukotriene C4-induced luteinizing hormone-releasing hormone release from immature and adult male rat median eminences in vitro: eicosanoid formation and binding parameters.  |  Gerozissis, K., et al. 1991. Prostaglandins. 41: 345-57. PMID: 1871376
  3. Prostaglandin E2 induced changes in renal blood flow, renal interstitial hydrostatic pressure and sodium excretion in the rat.  |  Long, CR., et al. 1990. Prostaglandins. 40: 591-601. PMID: 2093936
  4. Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release.  |  Raud, J., et al. 1988. Proc Natl Acad Sci U S A. 85: 2315-9. PMID: 2451246
  5. Delayed-onset synergism between leukotriene B4 and prostaglandin E2 in human skin.  |  Archer, CB., et al. 1987. Prostaglandins. 33: 799-805. PMID: 2823313
  6. Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro.  |  Kuno, S., et al. 1986. Proc Natl Acad Sci U S A. 83: 3487-90. PMID: 3010301
  7. Sleep-wake regulation by prostaglandins D2 and E2.  |  Hayaishi, O. 1988. J Biol Chem. 263: 14593-6. PMID: 3049580
  8. Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males.  |  Kuno, S., et al. 1986. Proc Natl Acad Sci U S A. 83: 2682-3. PMID: 3458226
  9. Resistance to Prostaglandin E2 Promotes Monocyte Activation During Chronic HIV Infection.  |  Di Diego Garcia, F., et al. 2023. J Infect Dis. 227: 423-433. PMID: 36482781
  10. Interleukin-1 increases cyclooxygenase-2 expression and prostaglandin E2 production in human granulosa-lutein cell via nuclear factor kappa B/P65 and extracellular signal-regulated kinase 1/2 signaling pathways.  |  Wan, S., et al. 2023. Mol Cell Endocrinol. 566-567: 111891. PMID: 36801432
  11. Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells.  |  Komatsu, M., et al. 2023. Toxicol Lett. 378: 39-50. PMID: 36863539
  12. Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest.  |  Lai, SF., et al. 2023. J Dermatol Sci.. PMID: 36872218
  13. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms.  |  Miller, TA. 1983. Am J Physiol. 245: G601-23. PMID: 6195926
  14. Effect of prostaglaidin endoperoxides and metabolites on bone resorption in vitro.  |  Raisz, LG., et al. 1977. Nature. 267: 532-4. PMID: 876371
  15. The vasodilator actions of isoprenaline, histamine, prostaglandin E2, glucagon and secretin on the hepatic arterial vascular bed of the dog.  |  Richardson, PD. and Withrington, PG. 1976. Br J Pharmacol. 57: 581-8. PMID: 963344

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PGE2, 1 mg

sc-201225
1 mg
$56.00

PGE2, 5 mg

sc-201225C
5 mg
$156.00

PGE2, 10 mg

sc-201225A
10 mg
$270.00

PGE2, 50 mg

sc-201225B
50 mg
$665.00

Is this product cell culture tested?

Asked by: TESA
This product has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols, e.g. using cell culture grade/sterilized solvents, aseptic technique, and sterilely filtering in a sterile hood.
Answered by: Technical Support
Date published: 2018-11-30

Is this prepared as an injectable?

Asked by: Pbellones
Thank you for your question. This biochemical is provided as a solid. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds. If you have any further questions, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: asia@scbio.cn or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2018-01-18

What is the source (synthetic/animal) of the compound?

Asked by: two2igm05
Thank you for your question. PGE2, sc-201225, is synthetic.
Answered by: Chemical Support 4
Date published: 2017-04-19

What is the expected appearance of this product?

Asked by: chemicalsmg
Thank you for your question. PGE2: sc-201225 is expected to be a white to pale yellow solid.
Answered by: Chemical Support 3
Date published: 2017-03-24

 Is this substance synthetic or from animal origin? 

Asked by: SCM4
This is supplied as synthetic PGE2.
Answered by: Tech Service 11
Date published: 2017-03-17

Is this product lyophilized?

Asked by: SCM4
The product is a crystalized solid, but, No, it has not been lyophilized.
Answered by: Tech Service 11
Date published: 2017-03-17
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Rated 5 out of 5 by from Charo et alCharo et al. (PubMed ID 23090667) found that PGE2 (prostaglandin E2), a key eicosanoid involved in neural, metabolic, and immune system function, regulated pancreatic stellate cell profibrotic activity via the EP4 receptor. -SCBT Publication Review
Date published: 2015-05-13
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PGE2 is rated 5.0 out of 5 by 1.
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