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PGE1 (Prostaglandin E1) (CAS 745-65-3)

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Synonym:Alprostadil; Edex; Caverject; Muse; Prostin VR
Application:A potent vasodilator
CAS Number:745-65-3
Purity:≥97%
Molecular Weight:354.48
Molecular Formula:C20H34O5
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
PGE1 (Prostaglandin E1) sc-201223 1 mg $22
PGE1 (Prostaglandin E1) sc-201223A 10 mg $135
Description
Prostaglandin E1 (PGE1) is a major prostaglandin found in human semen that inhibits platelet aggregation. The compound has documented mouse Ki values of 1.1, 2.1, 3.6, 10 and 13 nM for the respective receptors EP3, EP4, EP1, EP2 and IP. Aside from the activity at EP receptors, PGE1 has also been shown to affect PKC, calcium movement, and adenylate cyclase yielding a multitude of physiological effects.
Technical Information
Physical State:Solid
Solubility:Soluble in ethanol (5 mg/ml), water, DMSO (~50 mg/ml), DMF (~50 mg/ml), PBS(pH 7.2) (~1.67 mg/ml), THF, acetone (10 g/l) at 25 °C, ethyl acetate, and methanol.
Storage:Store at -20° C
Melting Point:114-115 °C
Boiling Point:529.28 °C at 760 mmHg
Density:~1.13 g/cm3 (Predicted)
Refractive Index:n20D ~1.55 (Predicted)
Optical Activity:α20/D -61.6º, c = 0.56% in Tetrahydrofuran for 578 nm spectral line
IC50:ADP-induced platelet aggregation: IC50 = 40 nM (human); Oryctolagus cuniculus: IC50 = 0.01 ug/mL; Prostanoid IP receptor: IC50 = 1.4 µM (human); Prostanoid EP4 receptor: EC5050 = 2.5 nM (mouse)
Ki Data:EP3 receptors: Ki= 1.1 nM (mouse); EP4 receptors: Ki= 2.6 nM (mouse); EP1 receptors: Ki= 36 nM (mouse); EP2 receptors: Ki= 10 nM (mouse); IP receptors: Ki= 33 nM (mouse)
pK Values:pKa: 4.77 (Predicted)
Safety and Reference Information
WGK Germany:3
RTECS:GY4569800
PubChem CID:5280723
Merck Index:14: 7876
MDL Number:MFCD00077860
EC Number:212-017-2
Beilstein Registry:5294062
SMILES:CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Mai, J., et al. 1980. Prostaglandins. 20: 187-197. PMID: 7413990
2. Speroff, L., et al. 1970. Am. J. Obstet. Gynecol. 107: 1111-1130. PMID: 4914185
3. Rubin, D. and Laposata, M. 1991. J. Biol. Chem. 266: 23618-23623. PMID: 1748640
4. Kloeze, J. 1969. Biochim. Biophys. Acta. 187: 285-292. PMID: 4981666
5. Kurstjens, N.P., et al. 1990. Biochem. Biophys. Res. Commun. 167: 1162-1169. PMID: 1690994
6. Kirtland, S.J. 1988. Prostaglandins Leukot. Essent. Fatty Acids. 32: 165-174. PMID: 2901111
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