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PGE1 (Prostaglandin E1) (CAS 745-65-3)

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Synonym:Alprostadil; Edex; Caverject; Muse; Prostin VR
Application:A potent vasodilator
CAS Number:745-65-3
Purity:≥97%
Molecular Weight:354.48
Molecular Formula:C20H34O5
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
PGE1 (Prostaglandin E1) sc-201223 1 mg $22
PGE1 (Prostaglandin E1) sc-201223A 10 mg $135
Description
Prostaglandin E1 (PGE1) is a major prostaglandin found in human semen that acts as a vasodilator, a fibrinolytic agent, and an inhibitor of platelet aggregation. Additionally, PGE1 has been shown to affect protein kinase C (PKC), calcium movement, and adenylate cyclase yielding a multitude of physiological effects.
Technical Information
Physical State:Solid
Solubility:Soluble in ethanol (5 mg/ml), water, DMSO (~50 mg/ml), DMF (~50 mg/ml), PBS(pH 7.2) (~1.67 mg/ml), THF, acetone (10 g/l) at 25 °C, ethyl acetate, and methanol.
Storage:Store at -20° C
Melting Point:114-115 °C
Boiling Point:529.28 °C at 760 mmHg
Density:~1.13 g/cm3 (Predicted)
Refractive Index:n20D ~1.55 (Predicted)
Optical Activity:α20/D -61.6º, c = 0.56% in Tetrahydrofuran for 578 nm spectral line
IC50:ADP-induced platelet aggregation: IC50 = 40 nM (human); Oryctolagus cuniculus: IC50 = 0.01 ug/mL; Prostanoid IP receptor: IC50 = 1.4 µM (human); Prostanoid EP4 receptor: EC5050 = 2.5 nM (mouse)
Ki Data:EP3 receptors: Ki= 1.1 nM (mouse); EP4 receptors: Ki= 2.6 nM (mouse); EP1 receptors: Ki= 36 nM (mouse); EP2 receptors: Ki= 10 nM (mouse); IP receptors: Ki= 33 nM (mouse)
pK Values:pKa: 4.77 (Predicted)
Safety and Reference Information
WGK Germany:3
RTECS:GY4569800
PubChem CID:5280723
Merck Index:14: 7876
MDL Number:MFCD00077860
EC Number:212-017-2
Beilstein Registry:5294062
SMILES:CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCCCCCC(=O)O)O)O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Mai, J., et al. 1980. Prostaglandins. 20: 187-197. PMID: 7413990
2. Speroff, L., et al. 1970. Am. J. Obstet. Gynecol. 107: 1111-1130. PMID: 4914185
3. Rubin, D. and Laposata, M. 1991. J. Biol. Chem. 266: 23618-23623. PMID: 1748640
4. Kloeze, J. 1969. Biochim. Biophys. Acta. 187: 285-292. PMID: 4981666
5. Kurstjens, N.P., et al. 1990. Biochem. Biophys. Res. Commun. 167: 1162-1169. PMID: 1690994
6. Kirtland, S.J. 1988. Prostaglandins Leukot. Essent. Fatty Acids. 32: 165-174. PMID: 2901111
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