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- Specifications
- Offered as 1 mg (sc-201167) and 5 mg (sc-201167A) sizes
- Synonym: Thyrocalcitonin
- CAS Number: 47931-85-1
- Molecular Weight: 3431.88
- Molecular Formula: C145H240N44O48S2
- Purity: ≥98%
- Derived from: Synthetic
- Physical Appearance: White to off-white powder
- Solubility: water (1mg/ml) or 0.05M acetic acid
- Sequence: Cys-Ser-Asn-Leu-Ser-Thr-Cys-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser- Gly-Thr-Pro-NH2
- SMILES: CC(C)CC1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O
)NC(C(=O)N1)CC(=O)N)
CO)N)C(=O)NC(C(C)C)C(=O)NC(CC
(C)C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(C)C)C
(=O)NC(
CO)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)
C)C(=O)NC(CC2=
CN=CN2)C(=O)NC(CCCCN)C(=O)NC(CC(C)C
)C(=O)NC(CCC(=O)N)C(=O)NC(C(C)O)C(=O)
NC(CC3=CC=C(
C=C3)O)C(=O)N4CCCC4C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)
O)C(=O)NC
(CC(=O)N)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO
)C(=O)NCC(=O)NC(C(C)O)C(=O)
N5CCCC5C(=O)N)C(C)O)CO
- Description
- Calcitonin, Salmon is a calcium regulating hormone secreted from mammalian thyroid parafollicular cells and in non-mammalian species from the ultimobranchial gland. Calcitonins are single chain polypeptides containing 32 amino-acid residues, showing hypocalcaemic and hypophosphatemic action, with amino-acid structure differing amongst mammalian species. Salmon calcitonin (salcatonin is the synthetic analogue) shows a markedly different sequence to that of the higher vertebrates as well as more potent activity. Eel calcitonin (Elcatonin) possesses a similar amino acid to that of the salmon form but is more stable than natural calcitonins because of the absence of disulfide bridges.
- Storage
- Safety
- Safety Statements: 22-24/25
- WGK Germany: 3
- RTECS: EV8000000
- For Research Use Only
- The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
- Reference Numbers
- PubChem Compound ID: 16129616
- Merck Index: 14: 1643
- MDL Number: MFCD00133859
- EC Number: 256-342-8
- References
- 1. Tenenhouse, A., et al. 1965. Proc. Natl. Acad. Sci. U.S.A. 53: 818-822. PMID: 14324540
2. Schlueter, R.J., et al. 1967. Endocrinology. 81: 854-860. PMID: 6042697
3. Stevenson, J.C., et al. 1981. Drugs. 21: 257-272. PMID: 7014170
4. Farley, J.R., et al. 1988. Endocrinology. 123: 159-167. PMID: 3383771
5. Poyner, D. 1995. Trends Pharmacol. Sci. 16: 424-428. PMID: 8578616
6. van Rossum, D., et al. 1997. Neurosci Biobehav Rev. 21: 649-678. PMID: 9353797
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Calcitonin, Salmon
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