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PKG Inhibitor (CAS 82801-73-8)

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Synonym:arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid
Application:A specific cyclic GMP-dependent protein kinase (cGKI) inhibitor
CAS Number:82801-73-8
Molecular Weight:943.11
Molecular Formula:C38H74N18O10
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
PKG Inhibitor sc-201161 1 mg $69
Description
PKG inhibitor is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of histones and has been used to study Plasmodium falciparum. NMDA potentiation and GABA nitric oxide depression have been reported to be blocked by the PKG inhibitor. Other PKG inhibitors include KT5823 (sc-3534), which activates apoptotic DNA fragmentation.
Technical Information
Physical State:Solid
Sequence:Arg-Lys-Arg-Ala-Arg-Lys-Glu
Solubility:Soluble in water.
Storage:Store at -20° C
Density:1.51 g/cm3
Refractive Index:n20D 1.66
Ki Data:PKG: Ki= 86 µM; PKA: Ki= 550 µM
Safety and Reference Information
WGK Germany:3
PubChem CID:134097
MDL Number:MFCD00080098
SMILES:C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(= O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Glass, D.B. 1983. Biochem. J. 213: 159-164. PMID: 6615418
2. Wexler, E.M., et al. 1998. J. Neurosci. 18: 2342-2349. PMID: 9502795
3. Wei, J.Y., et al. 2002. Brain Res. 927: 42-54. PMID: 11814431
4. Chan, S.L. and Fiscus, R.R. 2003. Mol. Hum. Reprod. 9: 775-783. PMID: 14614039
5. Diaz, C.A., et al. 2006. Mol. Biochem. Parasitol. 146: 78-88. PMID: 16325279
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