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N-Desmethylclozapine (CAS 6104-71-8)

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Application:A metabolite of clozapine and neurotransmitter
CAS Number:6104-71-8
Purity:99%
Molecular Weight:312.8
Molecular Formula:C17H17ClN4
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
N-Desmethylclozapine sc-201113 5 mg $83
N-Desmethylclozapine sc-201113A 25 mg $328
Description
N-Desmethylclozapine (NDMC), a major metabolite of clozapine (sc-200402), has been found to act as an antagonist of phosphoinositide hydrolysis stimulated by serotonin receptors. NDMC has been shown to be a potent antagonist of SR-2C (aka: 5HT2C), and has been reported to act as a moderate agonist of the rat native and human recombinant mAChR M1(CHRM1). N-Desmethylclozapine is an activator of D2DR and D3DR.
Technical Information
Physical State:Solid
Solubility:Soluble in ethanol (25 mg/ml), DMSO (>44 mg/ml), chloroform, and methanol.
Storage:Store at room temperature
Melting Point:183-184 °C
Boiling Point:502.55 °C at 760 mmHg (Predicted)
Density:1.38 g/mL (Predicted)
Refractive Index:n20D 1.71 (Predicted)
IC50:HERG: IC50 = 4490 nM (human); Muscarinic acetylcholine receptor M1: EC5050 = 18 nM (human)
Ki Data:Muscarinic acetylcholine receptor M5: Ki= 51 nM (human); Muscarinic acetylcholine receptor M3: Ki= 90 nM (human)
pK Values:pKb: 8.50
Safety and Reference Information
WGK Germany:3
PubChem CID:2820
MDL Number:MFCD00210189
SMILES:C1CN(CCN1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Kuoppamäki, M., et al. 1993. Eur. J. Pharmacol. 245: 179-182. PMID: 8387927
2. Thomas, D.R., et al. 2010. Neuropharmacology. 58: 1206-1214. PMID: 20206188
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