Molecular structure of Anpirtoline hydrochloride, CAS Number: 98330-05-3
Anpirtoline hydrochloride (CAS 98330-05-3)
Alternate Names:
2-Chloro-6-piperidin-4-ylsulfanylpyridine hydrochloride
Application:
Anpirtoline hydrochloride is a SR-1B agonist
CAS Number:
98330-05-3
Purity:
99%
Molecular Weight:
265.20
Molecular Formula:
C10H13ClN2S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Anpirtoline hydrochloride is a selective agonist of SR-1B. Anpirtoline shows strong selectivity at SR-1B (Ki = 28 nM) over the SR-1A (Ki = 150 nM) and SR-2 (Ki = 1.49 μM) serotonin receptor subtypes. Anpirtoline is also described to produce antagonism at the SR-3 (Ki = 29.5 nM).
Anpirtoline hydrochloride (CAS 98330-05-3) References
- Regulation of striatal dopamine release through 5-HT1 and 5-HT2 receptors. | Ng, NK., et al. 1999. J Neurosci Res. 55: 600-7. PMID: 10082082
- Synthesis and analgesic activity of some condensed analogs of anpirtoline. | Rádl, S., et al. 1999. Arch Pharm (Weinheim). 332: 208-12. PMID: 10399490
- Enhanced 5-HT metabolism and synthesis rate by the new selective r5-HT1B receptor antagonist, NAS-181 in the rat brain. | Stenfors, C., et al. 2000. Neuropharmacology. 39: 553-60. PMID: 10728876
- Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition. | Dulawa, SC., et al. 2000. Neuropsychopharmacology. 22: 650-9. PMID: 10788764
- Pharmacological characterisation of the decrease in 5-HT synthesis in the mouse brain evoked by the selective serotonin re-uptake inhibitor citalopram. | Stenfors, C., et al. 2001. Naunyn Schmiedebergs Arch Pharmacol. 363: 222-32. PMID: 11218075
- Oral drug self-administration in the home cage of mice: alcohol-heightened aggression and inhibition by the 5-HT1B agonist anpirtoline. | Miczek, KA. and de Almeida, RM. 2001. Psychopharmacology (Berl). 157: 421-9. PMID: 11605102
- Aggression escalated by social instigation or by discontinuation of reinforcement ('frustration') in mice: inhibition by anpirtoline: a 5-HT1B receptor agonist. | de Almeida, RM. and Miczek, KA. 2002. Neuropsychopharmacology. 27: 171-81. PMID: 12093591
- D-16949 (anpirtoline): a novel serotonergic (5-HT1B) psychotherapeutic agent assessed by its discriminative effects in the rat. | Swedberg, MD., et al. 1992. J Pharmacol Exp Ther. 263: 1015-22. PMID: 1335050
- Anpirtoline, a novel, highly potent 5-HT1B receptor agonist with antinociceptive/antidepressant-like actions in rodents. | Schlicker, E., et al. 1992. Br J Pharmacol. 105: 732-8. PMID: 1628159
- Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study. | Watanabe, A., et al. 2006. Nucl Med Biol. 33: 325-32. PMID: 16631081
- Hypothalamic neuropeptide Y (NPY) gene expression is not affected by central serotonin in the rainbow trout (Oncorhynchus mykiss). | Mancebo, MJ., et al. 2013. Comp Biochem Physiol A Mol Integr Physiol. 166: 186-90. PMID: 23752124
- The involvement of 5-HT-like receptors in the regulation of food intake in rainbow trout (Oncorhynchus mykiss). | Pérez Maceira, JJ., et al. 2014. Comp Biochem Physiol C Toxicol Pharmacol. 161: 1-6. PMID: 24365333
- 5-HT3 receptor antagonism by anpirtoline, a mixed 5-HT1 receptor agonist/5-HT3 receptor antagonist. | Göthert, M., et al. 1995. Br J Pharmacol. 114: 269-74. PMID: 7881726
Activator of:
SR-1A, and SR-1B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Anpirtoline hydrochloride, 5 mg | sc-201108 | 5 mg | $119.00 | |||
Anpirtoline hydrochloride, 25 mg | sc-201108A | 25 mg | $453.00 |