Venlafaxine Hydrochloride (CAS 99300-78-4)

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Application:	An inhibitor of ST and SLC6A2
CAS Number:	99300-78-4
Purity:	98%
Molecular Weight:	313.9
Molecular Formula:	C₁₇H₂₇NO₂ HCl

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
Venlafaxine Hydrochloride	sc-201102	10 mg	$60
Venlafaxine Hydrochloride	sc-201102A	50 mg	$240

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

Description

Venlafaxine Hydrochloride is a dual ST and SLC6A2 (serotonin and noradrenalin re-uptake) inhibitor that displays ~ 30-fold higher affinity for ST (SERT) (K_i = 82 nm) than SLC6A2 (NET) (K_i = 2480 nM).

Technical Information

Appearance:	White
Physical State:	Solid
Solubility:	Soluble in water (>25 mg/ml), and DMSO (50 mM).
Storage:	Store at room temperature
Melting Point:	217 °C
Boiling Point:	397.6 °C at 760 mmHg
Ki Data:	SERT: K_i= 82 nM; NET: K_i= 2480 nM

Safety and Reference Information

Transport:	UN 3077, Class 9, Packing group III
WGK Germany:	3
RTECS:	GV8872760
PubChem CID:	62923
Merck Index:	14: 9946
MDL Number:	MFCD03658865
SMILES:	Cl.COC1=CC=C(C=C1)C(CN(C)C)C1(O)CCCCC1

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Holdcroft, C. 1994. Nurse Pract. 19: 21. PMID: 7816367
2. Holliday, S.M. and Benfield, P. 1995. Drugs. 49: 280-294. PMID: 7729333
3. Bymaster, F.P., et al. 2001. Neuropsychopharmacology. 25: 871-880. PMID: 11750180
4. Stahl, S.M., et al. 2005. CNS Spectr. 10: 732-747. PMID: 16142213
5. Shams, M.E., et al. 2006. J Clin Pharm Ther. 31: 493-502. PMID: 16958828
6. Blier, P., et al. 2007. Int. J. Neuropsychopharmacol. 10: 41-50. PMID: 16690005
7. Berrocoso, E. and Mico, J.A. 2007. J. Pharmacol. Exp. Ther. 322: 101-107. PMID: 17431134

SDS

Datasheet/SDS