Grayanotoxin III Hemi(ethyl acetate) (CAS 4678-45-9)

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Synonym:	Andromedol
Application:	A Na+ channel modulator and excitotoxin
CAS Number:	4678-45-9
Purity:	≥90%
Molecular Weight:	414.5
Molecular Formula:	C₂₀H₃₄O₆•0.5C₄H₈O₂

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

Description

Grayanotoxin III is a member of the family of Grayanotoxins isolated from the flowers of Rhododendron and from honey derived from the flowers. Grayanotoxin III modulates Na⁺ ion channels at inhibitory and excitatory nerve terminals and affects the polarization states of the channels. This produces an effect on the voltage-dependent Ca²⁺ channels, increasing influx of Ca²⁺, and leading to subsequent release of GABA and glutamates and presentation of excitotoxicity.

Technical Information

Appearance:	White powder
Physical State:	Solid
Solubility:	Soluble in hot water, alcohol, acetic acid, hot chloroform, DMSO (10 mg/ml), and 100% ethanol (10 mg/ml).
Storage:	Desiccate at -20° C
Refractive Index:	n²⁰_D 1.62 (Predicted)

Safety and Reference Information

Transport:	UN 2811, Class 6.1, Packing group III
WGK Germany:	3
RTECS:	PB9190000
Merck Index:	14: 4543
MDL Number:	MFCD00285883
SMILES:	C[C@]3(C[C@@]24C[C@H]([C@]1([C@@H](C[C@@H](C1(C)C)O)[C@]([C@@H]2CCC3C4O)(C)O )O)O)O.CC(=O)OC.C[C@]7(C[C@@]68C[C@H]([C@]5([C@@H](C[C@@H](C5(C)C)O)[C@]([C@ @H]6CCC7C8O)(C)O)O)O)O

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Hotta, Y., et al. 1980. Arch. Toxicol. 44: 259-267. PMID: 7396712
2. Brown, B.S., et al. 1981. Eur. J. Pharmacol. 75: 271-281. PMID: 7318913
3. Seyama, I., et al. 1981. J. Pharmacol. Exp. Ther. 219: 614-624. PMID: 6271947
4. Narahashi, T. 1981. J. Physiol. 77: 1093-1101. PMID: 6286960
5. Yakehiro, M., et al. 2000. Mol. Pharmacol. 58: 692-700. PMID: 10999938
6. Kim, S.E., et al. 2010. Neurotoxicology. 31: 230-238. PMID: 20038438

SDS

Datasheet/SDS