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Octylonium Bromide (CAS 26095-59-0)

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Application:A PAF-R inhibitor
CAS Number:26095-59-0
Purity:98%
Molecular Weight:563.6
Molecular Formula:C29H43N2O4Br
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Octylonium Bromide sc-201035 5 mg $154
Octylonium Bromide sc-201035A 25 mg $583
Description
Octylonium Bromide has been reported to antagonize PAF (platelet-activating factor) induced aggregation of rabbit platelet-rich plasma, hypotension in rats, lethality in mice, and bronchoconstriction in guinea-pigs. This compound also demonstrates the ability to potently block neuronal nicotinic acetylcholine receptors and also a mild wide-spectrum Ca2+ channel blocker in bovine adrenal chromaffin cells. Additionally, Octylonium Bromide has been shown to inhibit muscular action potentials carried by L-type Ca2+ current. Octylonium Bromide is an inhibitor of PAF-R.
Technical Information
Physical State:Solid
Solubility:Soluble in water (12 mg/mL), DMSO (>25 mg/mL), ethanol (>25 mg/mL), and methanol.
Storage:Store at -20° C
Melting Point:166-168 °C
Safety and Reference Information
RTECS:BP7610000
PubChem CID:72092
EC Number:247-457-4
SMILES:[Br-].CCCCCCCCOC1=CC=CC=C1C(=O)NC1=CC=C(C=C1)C(=O)OCC[N+](C)(CC)CC
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Subissi, A., et al. 1989. Arch Int Pharmacodyn Ther. 302: 255-267. PMID: 2636821
2. Gandía, L., et al. 1996. Br. J. Pharmacol. 117: 463-470. PMID: 8821535
3. Martin, M.T., et al. 2004. Neurogastroenterol. Motil. 16: 175-183. PMID: 15086871
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